Related Experiment Video
Updated: Feb 8, 2026
10:46
MRI and PET in Mouse Models of Myocardial Infarction
Published on: December 19, 2013
12.4K
Stomach interference in 82Rb-PET myocardial perfusion imaging
Thomas Rasmussen1, Andreas Kjær2, Philip Hasbak2
1Department of Clinical Physiology, Nuclear Medicine & PET and Cluster for Molecular Imaging, Department of Biomedical Sciences, Rigshospitalet and University of Copenhagen, Blegdamsvej 9, 2100, Copenhagen, Denmark. drrasmussen@hotmail.com.
Summary
82Rubidium PET myocardial perfusion imaging (MPI) interference is reduced with stress imaging. Large stomach volume increases interference, especially in smaller patients, highlighting the importance of fasting before 82Rb PET scans.
Area of Science:
- Cardiology
- Nuclear Medicine
- Radiology
Background:
- 82Rubidium (82Rb) PET myocardial perfusion imaging (MPI) can suffer from artifacts, similar to SPECT MPI.
- Excessive subdiaphragmatic activity, particularly from the stomach, can interfere with 82Rb PET MPI interpretation.
Purpose of the Study:
- To investigate the relationship between clinical parameters and MPI interference in 82Rb PET.
- To assess the correlation between stomach volume and the severity of MPI interference.
Main Methods:
- Two hundred patients underwent a standard 2-hour fasting protocol before 82Rb PET MPI.
- Images were analyzed for radiotracer interference between the left ventricle and extracardiac activity.
- Stomach volume was measured, and its association with interference severity was evaluated.
Main Results:
- Interference, mainly from stomach 82Rb activity, was less severe during stress PET compared to rest PET (46% vs. 31% absent, P < 0.05).
- A large stomach volume correlated with more severe interference during rest imaging (P < 0.05).
- Higher body mass index (BMI) was associated with less interference.
Conclusions:
- Body Mass Index (BMI) is a significant predictor of MPI interference.
- Increased stomach volume is linked to more severe MPI interference, emphasizing the need for adequate fasting.
- Optimizing fasting protocols may improve 82Rb PET MPI interpretation, particularly in smaller patients.
Related Concept Videos
02:18Interference and Diffraction
52.5K
Interference is a characteristic phenomenon exhibited by waves. When two electromagnetic waves interact with their peaks and troughs coinciding, a resulting wave with enhanced amplitude is produced. This is known as constructive interference. In this case, the two waves interacting are in phase with each other.
52.5K
01:21Stomach pH Regulation
7.3K
The human body carefully regulates the internal pH of different organs to maintain homeostasis. For example, while the blood plasma maintains a neutral pH of 7, the stomach lumen has an acidic pH of 1.5 - 3.5. The low pH of stomach lumen helps kill pathogens in the food and break down complex food molecules.
The acid-secreting gastric mucosal epithelial cells (parietal cells) lining the stomach lumen maintain the low pH in the lumen. Numerous ion transporters and channels on these parietal...
The acid-secreting gastric mucosal epithelial cells (parietal cells) lining the stomach lumen maintain the low pH in the lumen. Numerous ion transporters and channels on these parietal...
7.3K
01:26Stomach Histology
3.2K
The stomach comprises several layers that work together to facilitate digestion and protect the organ. The outermost layer is called the serosa, which provides support and protection to the stomach. The muscularis externa layer is responsible for the mechanical breakdown of food by contracting and moving the stomach. The submucosa layer, located beneath the muscularis externa, contains connective tissue, blood vessels, nerves, and glands that secrete mucus and other substances essential for...
3.2K
01:23RNA Interference
28.2K
RNA interference (RNAi) is a process in which a small non-coding RNA molecule blocks the post-transcriptional expression of a gene by binding to its messenger RNA (mRNA) and preventing the protein from being translated.
This process occurs naturally in cells, often through the activity of genomically-encoded microRNAs. Researchers can take advantage of this mechanism by introducing synthetic RNAs to deactivate specific genes for research or therapeutic purposes. For example, RNAi could be used...
This process occurs naturally in cells, often through the activity of genomically-encoded microRNAs. Researchers can take advantage of this mechanism by introducing synthetic RNAs to deactivate specific genes for research or therapeutic purposes. For example, RNAi could be used...
28.2K
01:16Gross Anatomy of the Stomach
3.2K
The human stomach is a vital part of the digestive system, performing multiple functions. It is located within the peritoneum, a serous membrane that lines the abdominal cavity. The stomach plays a central role in processing food substances and interacts with other digestive organs through coordinated digestive processes. The stomach has a characteristic J-shape and is divided into four main regions. The cardia is the first section where the esophagus connects to the stomach and is the entry...
3.2K
01:25Mucosal Barrier of the Stomach
2.4K
The gastric glands contain parietal cells that secrete hydrochloric acid (HCl) for digestion. The cells secrete HCl because it is highly corrosive and essential for breaking down food. To achieve this, they secrete hydrogen and chloride ions into the lumen of the gastric glands, which combine to form HCl.
Within parietal cells, carbonic acid is first formed through the reaction of water and carbon dioxide. The dissociation of carbonic acid releases bicarbonate and hydrogen ions. The bicarbonate...
Within parietal cells, carbonic acid is first formed through the reaction of water and carbon dioxide. The dissociation of carbonic acid releases bicarbonate and hydrogen ions. The bicarbonate...
2.4K