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Updated: Feb 8, 2026

The Mouse Cremaster Muscle Preparation for Intravital Imaging of the Microcirculation

The Mouse Cremaster Muscle Preparation for Intravital Imaging of the Microcirculation

Published on: June 10, 2011

Dyslipidemias and Microcirculation.

Teresa Padró^1,2, Gemma Vilahur^1,2, Lina Badimon^1,2,3

¹Cardiovascular ICCC- Program, Research Institute Hospital de la Santa Creu i Sant Pau, IIB-Sant Pau, Barcelona, Spain.

Current Pharmaceutical Design

|July 4, 2018

Summary

Dyslipidemia, particularly high LDL cholesterol, impairs microvascular function and contributes to cardiovascular disease. This review explores how high cholesterol affects small blood vessels and the heart, impacting nitric oxide bioavailability and promoting inflammation.

Keywords:

Hyperdcholesterolemia NO-bioavailability cardiovascular-risk-factors coronary-microvascular-dysfunction; endothelial- function inflammation lipoproteins microvasculature.

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Last Updated: Feb 8, 2026

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Published on: June 10, 2011

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Published on: November 18, 2010

Microiontophoresis and Micromanipulation for Intravital Fluorescence Imaging of the Microcirculation

Microiontophoresis and Micromanipulation for Intravital Fluorescence Imaging of the Microcirculation

Published on: June 10, 2011

Area of Science:

Cardiovascular Medicine
Endocrinology

Background:

Dyslipidemia is a major risk factor for atherosclerosis in large arteries.
Emerging evidence indicates high cholesterol adversely affects microvasculature before overt atherosclerosis.
Hypercholesterolemia can worsen outcomes post-myocardial infarction in preclinical models.

Purpose of the Study:

To review evidence linking dyslipidemia, specifically high LDL-C, to microvascular dysfunction.
To elucidate mechanisms by which high cholesterol induces microvascular functional alterations.
To discuss the impact of dyslipidemia-induced microvascular dysfunction on the myocardium.

Main Methods:

Literature review of preclinical and clinical studies.
Analysis of pathogenic mechanisms of microvascular dysfunction in hypercholesterolemia.
Examination of functional and structural changes in the microvasculature.

Main Results:

High cholesterol impairs endothelium-dependent vasodilation via reduced nitric oxide bioavailability.
Mechanisms include increased arginase activity, free radical production, and leukocyte activation.
Microvascular dysfunction promotes a proinflammatory and prothrombotic state, affecting platelet adhesion.

Conclusions:

Dyslipidemia significantly contributes to microvascular dysfunction.
This dysfunction plays a critical role in cardiovascular disease pathogenesis.
Understanding these mechanisms is crucial for developing targeted therapies.