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Updated: Feb 8, 2026

Evidence-based Knowledge Synthesis and Hypothesis Validation: Navigating Biomedical Knowledge Bases via Explainable AI and Agentic Systems
Published on: June 13, 2025
Knowledge Management for Brazilian Cancer Care Services
Antônio Augusto Gonçalves1, Sandro Luís Freire de Castro Silva1, Carlos Henrique Fernandes Martins1
1Instituto Nacional de Câncer - COAE Tecnologia da Informação, Rio de Janeiro, Brazil.
This study developed a decision support system to reduce cancer patient waiting times in Brazil. By identifying bottlenecks and simulating patient flow, the system aims to improve early diagnosis and treatment access for better patient outcomes.
Area of Science:
- Oncology
- Health Services Research
- Operations Research
Background:
- Brazil faces a complex cancer care scenario with nearly 600,000 new cases annually.
- Long waiting queues for cancer diagnosis and treatment are common, impacting patient quality of life and cure rates.
- Early diagnosis and timely initiation of treatment are critical for improving cancer patient outcomes.
Purpose of the Study:
- To develop a decision support system (DSS) to optimize cancer patient flow in Brazil.
- The DSS aims to improve the identification of access alternatives and appointment scheduling.
- The goal is to reduce patient waiting times for cancer treatment initiation.
Main Methods:
- The Theory of Constraints (TOC) was applied to identify bottlenecks in the patient treatment pathway.
- Discrete Events Simulation (DES) modeling was utilized to analyze and reduce patient waiting times.
- The study focused on improving resource allocation and scheduling within cancer care services.
Main Results:
- The developed DSS effectively identifies critical bottlenecks in cancer patient care pathways.
- Discrete Events Simulation demonstrated a significant potential for reducing patient waiting times.
- The system facilitates improved appointment scheduling and resource utilization for cancer treatment.
Conclusions:
- The integration of TOC and DES provides a robust framework for addressing inefficiencies in cancer care.
- The decision support system offers a viable solution to mitigate long waiting times for cancer patients in Brazil.
- Optimizing patient flow through such systems can enhance treatment accessibility, quality of life, and survival rates.
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