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3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache
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Brain structure and function related to headache: Brainstem structure and function in headache.

Marta Vila-Pueyo1, Jan Hoffmann2, Marcela Romero-Reyes3

  • 1Headache Group, Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.

Cephalalgia : an International Journal of Headache
|July 4, 2018
PubMed
Summary
This summary is machine-generated.

The brainstem plays a key role in primary headache disorders like migraine. Specific brainstem areas are activated during headaches, influencing pain and other neurological symptoms.

Keywords:
Primary headachescluster headachemedullamidbrainmigrainepons

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Area of Science:

  • Neuroscience
  • Neurology
  • Headache Medicine

Background:

  • Primary headache disorders (e.g., migraine, cluster headache) are complex brain disorders.
  • These conditions involve not only head pain but also sensory, homeostatic, autonomic, cognitive, and affective symptoms.
  • Brainstem activation is frequently observed in neuroimaging studies of headache disorders, particularly migraine.

Purpose of the Study:

  • To review and discuss the existing literature on the role of brainstem structure and function in primary headache disorders.
  • To elucidate the functional significance of specific brainstem nuclei in headache mechanisms.
  • To explore the relationship between brainstem activity and the diverse symptoms associated with headaches.

Main Methods:

  • Literature review and synthesis of existing research.
  • Analysis of neuroimaging findings related to brainstem activation in headache patients.
  • Examination of preclinical studies investigating brainstem nuclei modulation and its effects on headache-related symptoms.

Main Results:

  • Brainstem areas, including medullary, pontine, and midbrain structures, show specific activation patterns associated with primary headaches.
  • Modulation of certain brainstem nuclei in preclinical models affects sensory processing, cranial autonomic responses, and homeostatic mechanisms relevant to headache.
  • The brainstem is implicated in the generation and modulation of headache pain and associated neurological symptoms.

Conclusions:

  • The brainstem is a critical structure involved in the pathophysiology of primary headache disorders.
  • Understanding brainstem function offers insights into the mechanisms underlying migraine and other headache types.
  • Targeting brainstem pathways may represent a future therapeutic strategy for headache management.