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Updated: Feb 8, 2026

Establishment of Gastric Cancer Patient-derived Xenograft Models and Primary Cell Lines
Published on: July 19, 2019
Systemic-inflammation-based score can predict prognosis in metastatic gastric cancer patients before first-line
Angelica Petrillo1, Maria Maddalena Laterza1, Giuseppe Tirino1
1University of Campania 'Luigi Vanvitelli' - School of Medicine, Department of Precision Medicine, Division of Medical Oncology, Via Pansini n.5, 80131 Naples, Italy.
Aim:
Systemic inflammatory response affects survival of gastric cancer (GC) patients. This study was carried out to create a prognostic inflammatory-based score to predict survival in metastatic GC (mGC) before first-line chemotherapy.
Materials & Methods:
We studied the prognostic value of neutrophil-lymphocyte ratio (NLR) and platelet-lymphocyte ratio in 151 patients with mGC at the diagnosis.
Results:
Median overall survival (OS) was significantly lower in patients with high NLR. Performance status 1-2 according to the Eastern Cooperative Oncology Group scale and NLR were predictors of shorter OS at multivariate analysis. Based on these results, we defined a prognostic OS score, showing a better median OS in favorable risk group.
Conclusion:
Elevated pretreatment NLR and Eastern Cooperative Oncology Group are independent predictors of shorter OS in mGC patients before first-line chemotherapy.
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