Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Dehydration Synthesis01:15

Dehydration Synthesis

150.1K
Overview
Dehydration synthesis (also called a condensation reaction) is the chemical process in which two molecules covalently link together to form a new molecule, along with the release of a water molecule. Many physiologically important compounds form by dehydration synthesis reactions, such as complex carbohydrates, proteins, DNA, and RNA.
Synthesis of carbohydrates
Sugar molecules are covalently linked together by dehydration synthesis. During the reaction, the hydroxyl (-OH) group from...
150.1K
Synthesis and Decomposition Reactions02:17

Synthesis and Decomposition Reactions

38.3K
Synthesis and decomposition are two types of redox reactions. Synthesis means to make something, whereas decomposition means to break something. The reactions are accompanied by chemical and energy changes. 
38.3K
Lagging Strand Synthesis01:59

Lagging Strand Synthesis

61.4K
During replication, the complementary strands in double-stranded DNA are synthesized at different rates. Replication first begins on the leading strand. Replication starts later, occurs more slowly, and proceeds discontinuously on the lagging strand.
There are several major differences between synthesis of the leading strand and synthesis of the lagging strand. 1) Leading strand synthesis happens in the direction of replication fork opening, whereas lagging strand synthesis happens in the...
61.4K
Lagging Strand Synthesis01:59

Lagging Strand Synthesis

16.8K
16.8K
Transfer RNA Synthesis02:36

Transfer RNA Synthesis

13.4K
One of the unique features of tRNA is the presence of modified bases. In some tRNAs, modified bases account for nearly 20% of the total bases in the molecule. Altogether, these unusual bases protect the tRNA from enzymatic degradation by RNases.
Each of these chemical modifications is carried by a specific enzyme, post-transcription. All of these enzymes have unique base and site-specificity. Methylation, the most common chemical modification, is carried by at least nine different enzymes, with...
13.4K
Transfer RNA Synthesis02:35

Transfer RNA Synthesis

3.7K
3.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Targeting RNA-Binding Oncofetal Protein IGF2BP3: Discovery of Potent and Selective Inhibitors.

Journal of medicinal chemistry·2026
Same author

Reactions of Strained Cycloalkanes with Radicals and Diradicaloids: The Roles of Diradical Character and Strain Release.

Journal of the American Chemical Society·2026
Same author

Rule-breaking in chemical synthesis.

Science advances·2026
Same author

Propellane Alkaloid Biosynthesis and Total Synthesis via Interrupted Reaction Pathways.

ACS central science·2026
Same author

Genome mining of unusual biosynthetic gene clusters.

The Journal of antibiotics·2026
Same author

Seven-Membered Azacyclic Allenes: Synthesis, Trapping, and Stereochemical Transfer Studies.

Journal of the American Chemical Society·2026

Related Experiment Video

Updated: Feb 8, 2026

In vitro Biofilm Formation in an 8-well Chamber Slide
06:14

In vitro Biofilm Formation in an 8-well Chamber Slide

Published on: January 20, 2011

43.5K

Synthesis of 8-Hydroxygeraniol.

Francesca M Ippoliti1, Joyann S Barber1, Yi Tang1

  • 1Department of Chemistry and Biochemistry , University of California , Los Angeles , California 90095 , United States.

The Journal of Organic Chemistry
|July 4, 2018
PubMed
Summary

A new two-step method converts geranyl acetate to 8-hydroxygeraniol using selenium dioxide oxidation. This efficient protocol simplifies the preparation of 8-hydroxygeraniol for biosynthetic studies.

More Related Videos

Measuring Composition of CD95 Death-Inducing Signaling Complex and Processing of Procaspase-8 in this Complex
07:17

Measuring Composition of CD95 Death-Inducing Signaling Complex and Processing of Procaspase-8 in this Complex

Published on: August 2, 2021

3.0K
Measuring the Induced Membrane Voltage with Di-8-ANEPPS
05:52

Measuring the Induced Membrane Voltage with Di-8-ANEPPS

Published on: November 19, 2009

18.1K

Related Experiment Videos

Last Updated: Feb 8, 2026

In vitro Biofilm Formation in an 8-well Chamber Slide
06:14

In vitro Biofilm Formation in an 8-well Chamber Slide

Published on: January 20, 2011

43.5K
Measuring Composition of CD95 Death-Inducing Signaling Complex and Processing of Procaspase-8 in this Complex
07:17

Measuring Composition of CD95 Death-Inducing Signaling Complex and Processing of Procaspase-8 in this Complex

Published on: August 2, 2021

3.0K
Measuring the Induced Membrane Voltage with Di-8-ANEPPS
05:52

Measuring the Induced Membrane Voltage with Di-8-ANEPPS

Published on: November 19, 2009

18.1K

Area of Science:

  • Organic Chemistry
  • Biochemistry
  • Synthetic Chemistry

Background:

  • Geranyl acetate is a precursor in terpene biosynthesis.
  • Monoterpene indole alkaloids have significant biological importance.
  • Efficient synthesis of key intermediates is crucial for biosynthetic studies.

Purpose of the Study:

  • To develop a simple and efficient protocol for synthesizing 8-hydroxygeraniol.
  • To facilitate further research into the biosynthesis of monoterpene indole alkaloids.

Main Methods:

  • A two-step conversion of geranyl acetate.
  • Selenium dioxide (SeO2)-promoted chemo- and regioselective oxidation.
  • Subsequent deacetylation of the oxidized intermediate.

Main Results:

  • Successful and operationally simple conversion of geranyl acetate to 8-hydroxygeraniol.
  • High efficiency and selectivity in the oxidation step.
  • Straightforward deacetylation yielding the target compound.

Conclusions:

  • The reported protocol provides a facile route to 8-hydroxygeraniol.
  • This method is expected to advance biosynthetic studies of monoterpene indole alkaloids.
  • The SeO2-promoted oxidation offers a valuable synthetic tool.