Attenuation profile matching: An accurate and scan parameter-robust measurement method for small airway dimensions in...

The dimensions of small airways with an internal diameter of less than 2-3 mm are important biomarkers for the evaluation of pulmonary diseases, such as asthma and chronic obstructive pulmonary disease (COPD). The resolution limitations of CT systems, however, have remained a barrier to be of use for determining the small airway dimensions. We present a novel approach, called the attenuation profile matching (APM) method, which allows for the accurate determination of the small airway dimension while being robust to varying CT scan parameters.

For generating the synthetic attenuation profiles of an airway, we acquired and employed the point spread functions of a CT system by calculating its convolution with numerical airway models with varying wall thicknesses. The dimensions of a given airway were determined as per the numerical model yielding minimum error between the measured and the synthetic attenuation profiles across the airway.

In a phantom study with airway tubes, the APM method proved to be highly accurate in determining airway wall dimensions. The measurement error for the smallest tube (0.6 mm thickness, 3 mm diameter) was merely 0.02 mm (3.3%) in wall thickness and 0.17 mm (5.6%) in lumen diameter. In a pilot clinical test, the APM method was able to distinguish the airway wall thicknesses of COPD cases (1.16 ± 0.23 mm) from those of normal subjects (0.6 ± 0.18 mm), while the measurements using the full width at half maximum method substantially overlapped (1.45 ± 0.32 mm vs. 1.28 ± 0.30 mm, respectively) and were barely distinguishable from each other.

Our proposed APM method has the potential to overcome the resolution limitations of current CT systems and accurately determine the small airway dimensions in COPD patients.