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High ANXA7 Potentiates Eucalyptol Toxicity in Hormone-refractory Prostate Cancer

Ximena Leighton1, Alakesh Bera1, Ofer Eidelman1

  • 1Department of Anatomy, Physiology, and Genetics, and Institute for Molecular Medicine, Uniformed Services University School of Medicine (USUHS), Bethesda, MD, U.S.A.

Anticancer Research
|July 5, 2018
PubMed
Abstract

Insights

Overexpressing the ANXA7 tumor suppressor gene enhances eucalyptol

Area of Science:

  • Oncology
  • Molecular Biology
  • Cancer Research

Background:

  • Annexin A7 (ANXA7) functions as a tumor suppressor gene.
  • ANXA7 is frequently lost in aggressive prostate cancers.
  • The role of ANXA7 in cancer drug sensitivity remains largely unexplored.

Purpose of the Study:

  • To investigate the role of ANXA7 in anticancer drug treatment.
  • To explore the correlation between ANXA7 expression and sensitivity to various compounds.
  • To determine if ANXA7 influences prostate cancer cell response to eucalyptol.

Main Methods:

  • Measured ANXA7 expression across 60 cancer cell lines (NCI-60 ADS).
  • Correlated ANXA7 levels with sensitivity to over 30,000 natural and synthetic compounds.
  • Investigated the effects of ANXA7 overexpression combined with eucalyptol on prostate cancer cells.

Main Results:

  • Eucalyptol demonstrated a strong positive correlation with ANXA7 expression.
  • Overexpressing ANXA7 significantly enhanced eucalyptol-induced cell death in castration-resistant prostate cancer.
  • Synergistic effects were observed, impacting gene expression profiles including Ras family, MDM4, NF-κB, and VEGF.

Conclusions:

  • ANXA7 overexpression potentiates eucalyptol's cytotoxic effects in prostate cancer.
  • This suggests a potential therapeutic strategy combining ANXA7 modulation with eucalyptol treatment.
  • ANXA7 and eucalyptol exhibit synergistic anticancer activity through specific molecular pathways.
Keywords:
ANXA7Anticancer Drug Screen (NCI-60 ADS)National Cancer Institute – 60 cancer cell line screening (NCI-60)Prostate cancerchemo-sensitivityeucalyptol

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