Related Experiment Video
Updated: Feb 8, 2026

Development of Compendium for Esophageal Squamous Cell Carcinoma
Published on: April 12, 2024
CD117 Expression in Squamous Cell Carcinoma of the Oesophagus
Luis Fernando Moreira1, Marcelo Marafon Maino2, Henrique Iahnke Garbin2
1Southern Surgical Oncology Group, HCPA University Attached Hospital, Faculty of Medicine, Rio Grande do Sul Federal University, Porto Alegre, Brazil lufmoreira@hcpa.edu.br.
Background/Aim:
Identification of changes in specific genes may help new attempts in finding targeted therapy for oesophageal cancer which still has a very poor prognosis. The aim of this study was to investigate CD117 expression in squamous cell carcinoma of the oesophagus (SCCO).
Materials And Methods:
A preliminary study was performed for CD177 immunoreactivity using a monoclonal antibody against CD117 on 27 SCCO specimens from patients who underwent surgical resection. Specimens of oesophageal mucosa obtained from 10 healthy individuals were studied as a control group.
Results:
Most patients had TNM American Joint Committee on Cancer stage IIb or III SCCO and mean overall survival was 21 (range=2-72) months. Cytoplasmic membrane CD117 immunoreactivity was demonstrated in only four (15%) out of 27 tumours and in none of the controls.
Conclusion:
Although immunohistochemical expression of CD117 was higher than previously demonstrated, the lack of expression does not warranty further use in targeted therapy of SCCO.
Related Concept Videos
Cell Specific Gene Expression
Cell Specific Gene Expression
Chromatin Position Affects Gene Expression
Topologically Associated Domains (TADs)
The 3-dimensional positioning of chromatin in the nucleus influences the...
What is Gene Expression?
Gene expression is the process in which DNA directs the synthesis of functional products, that is, proteins. Cells can regulate gene expression at various stages. It allows organisms to generate different cell types and enables cells to adapt to internal and external factors.
Genetic Information Flows from DNA to RNA to Protein
A gene is a stretch of DNA that serves as the blueprint for functional RNAs and proteins. Since DNA is made up of nucleotides and proteins consist of amino...
What is Gene Expression?
Expressing Solution Concentration
Concentrations may be quantitatively assessed using a wide variety of measurement units, each convenient for particular applications. Molarity (M) is a useful concentration unit for many applications in chemistry.

