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Related Concept Videos

lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

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In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
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PIWI-interacting RNAs, or piRNAs, are the most abundant short non-coding RNAs. More than 20,000 genes have been found in humans that code for piRNAs while only 2000 genes have been found for miRNAs. piRNAs can act at the transcriptional and post-transcriptional levels and have a vital role in silencing transposable elements present in germ cells. They are also involved in epigenetic silencing and activation. Previously, they were thought to function only in germ cells but new evidence suggests...
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Related Experiment Video

Updated: Feb 8, 2026

Isolation of Small Noncoding RNAs from Human Serum
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Long noncoding RNAs in cervical cancer.

Dan Shi1, Cheng Zhang2, Xiaodong Liu3

  • 1Key Laboratory of Radiobiology (Ministry of Health), School of Public Health, Jilin University; Department of Radiation Oncology China-Japan Union Hospital of Jilin University, Changchun, China.

Journal of Cancer Research and Therapeutics
|July 5, 2018
PubMed
Summary

Long noncoding RNAs (lncRNAs) play a crucial role in regulating cervical cancer development. Understanding lncRNA mechanisms offers new avenues for targeted cervical cancer treatments.

Keywords:
Cervical cancerlong noncoding RNAsnoncoding RNAsreview

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Area of Science:

  • Molecular Biology
  • Oncology
  • Genetics

Background:

  • Long noncoding RNAs (lncRNAs) were initially considered non-functional due to their lack of protein-coding potential.
  • Recent research highlights the significant regulatory roles of lncRNAs in various biological processes, including disease development.

Purpose of the Study:

  • To review the critical role of lncRNAs in cervical cancer.
  • To elucidate the mechanisms by which lncRNAs regulate cervical cancer progression.
  • To identify potential therapeutic targets for cervical cancer treatment.

Main Methods:

  • Literature review and synthesis of existing research on lncRNAs and cervical cancer.
  • Analysis of the functional characteristics and regulatory mechanisms of key lncRNAs involved in cervical cancer.
  • Exploration of potential therapeutic strategies targeting lncRNAs.

Main Results:

  • Specific lncRNAs are identified as crucial regulators in cervical cancer.
  • lncRNAs exhibit diverse mechanisms in modulating cervical cancer development and progression.
  • lncRNAs present promising targets for novel therapeutic interventions.

Conclusions:

  • lncRNAs are integral to the pathogenesis of cervical cancer.
  • Further investigation into lncRNA functions can lead to the development of targeted therapies.
  • Targeting lncRNAs holds potential for improving cervical cancer treatment outcomes.