Target cell prolactin, II

Is the entry hypothesis compatible with all the existing data about "the" second messenger for prolactin listed in Section II? All of these messengers, in some way either participate in, or modify, prolactin's actions or, in an end point-dependent manner, may actually mimic prolactin. There remains considerable uncertainty as to whether these findings reflect phenomena, some independent of and others quite dependent upon entry, on the one hand, or merely portions of a relatively large number of molecular cascades, some (but not necessarily all) begun initially at the plasmalemma and many (if not all) orchestrated toward completion by intracellular prolactin or agonist-receptor complex.