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Related Experiment Videos

Target cell prolactin, II.

J M Nolin

    International Review of Cytology
    |January 1, 1985
    PubMed
    Summary

    The exact second messenger for prolactin remains uncertain, with identified molecules either modifying prolactin actions or mimicking its effects. Further research is needed to clarify these complex intracellular signaling pathways.

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    Area of Science:

    • Endocrinology
    • Molecular Biology
    • Cell Signaling

    Background:

    • Prolactin is a key hormone with diverse physiological roles.
    • The precise molecular mechanisms underlying prolactin signaling are not fully elucidated.
    • Several intracellular molecules have been proposed as potential second messengers for prolactin.

    Purpose of the Study:

    • To evaluate the compatibility of the entry hypothesis with existing data on prolactin's second messenger.
    • To clarify the roles of various proposed messengers in prolactin's actions.
    • To understand the complex molecular cascades involved in prolactin signaling.

    Main Methods:

    • Review and analysis of existing scientific literature on prolactin signaling.
    • Comparison of the entry hypothesis with data on identified prolactin-associated molecules.
    • Examination of the interplay between cell surface and intracellular events in prolactin action.

    Main Results:

    • Existing data present considerable uncertainty regarding a single, definitive second messenger for prolactin.
    • Identified molecules either modulate prolactin's effects or, in certain contexts, replicate them.
    • The findings suggest a complex network of signaling pathways, potentially initiated at the plasma membrane and involving intracellular cascades.

    Conclusions:

    • The entry hypothesis's compatibility with current data is uncertain.
    • Prolactin's actions are mediated by a complex system of interacting molecular cascades, rather than a single second messenger.
    • Further investigation is required to fully map the intracellular signaling orchestrated by prolactin or its receptor complex.

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