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Ventricular bigeminal rhythm associated with trastuzumab: A potential cardiac side effect
Mustafa Karaca1, Hakan Kocoglu2, Irem Bilgetekin1
1Department of Internal Medicine; Department of Medical Oncology, Gazi University Medical School, Ankara, Turkey.
Journal of Cancer Research and Therapeutics
|July 5, 2018
Summary
Trastuzumab, a targeted chemotherapy, can cause cardiac side effects like asymptomatic ventricular bigeminal rhythm. This case report highlights the importance of monitoring cardiac function during such treatments.
Area of Science:
- Cardiology
- Oncology
- Pharmacology
Background:
- Cardiac side effects of targeted chemotherapy are an emerging concern.
- Limited studies exist due to challenges in controlled group establishment and multifactorial cardiac symptom origins.
- Case reports offer valuable insights into chemotherapy-induced cardiotoxicity.
Observation:
- A patient undergoing treatment with trastuzumab developed cardiac complications.
- The patient presented with asymptomatic ventricular bigeminal rhythm.
- Electrocardiography confirmed the observed rhythm alteration.
Findings:
- Trastuzumab treatment was associated with asymptomatic ventricular bigeminal rhythm.
- This finding contributes to the spectrum of cardiac side effects linked to targeted agents.
- The case underscores the importance of cardiac monitoring during specific cancer therapies.
Implications:
- Further investigation into trastuzumab's cardiotoxicity is warranted.
- Case reports are vital for identifying rare or asymptomatic adverse drug reactions.
- Enhanced understanding can improve patient management and reduce chemotherapy-related cardiac morbidity.
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