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Label-Free Immunoprecipitation Mass Spectrometry Workflow for Large-scale Nuclear Interactome Profiling

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Published on: November 17, 2019

A 44-year-old man with hemoptysis.

Raju Pangeni¹, Saurabh Mittal¹, Sudheer Arava²

¹Department of Pulmonary Medicine and Sleep Disorders, All India Institute of Medical Sciences, New Delhi, India.

Lung India : Official Organ of Indian Chest Society

|July 5, 2018

Summary

A patient with systemic sclerosis developed an endotracheal mass and skin lesions, leading to airway obstruction. This case highlights rare presentations and management of such conditions.

Keywords:

Bronchoscopy central airway obstruction histoplasmosis

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Area of Science:

Pulmonology
Dermatology
Cardiology

Background:

A 44-year-old male with diffuse cutaneous systemic sclerosis and dilated cardiomyopathy on immunosuppressants presented with cough and hemoptysis.
Clinical and radiological findings suggested an endotracheal mass.

Purpose of the Study:

To discuss differential diagnoses for endotracheal masses and skin lesions in immunocompromised patients.
To review management options for central airway obstruction caused by such masses.

Main Methods:

Case presentation of a patient with systemic sclerosis.
Review of clinicoradiological findings.
Discussion of differential diagnoses and management strategies.

Main Results:

The patient developed nodular skin lesions and progressive tracheal mass growth.
Central airway obstruction occurred due to the increasing tracheal mass.

Conclusions:

This case underscores the importance of considering rare presentations of systemic sclerosis complications.
Prompt diagnosis and multidisciplinary management are crucial for airway obstruction and skin manifestations.