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Interplay between Oxidative Stress and Platelet Activation in Coronary Thrombus of STEMI Patients

Camilla Calvieri1, Gaetano Tanzilli2, Simona Bartimoccia3

  • 1Department of Cardiovascular, Respiratory, Nephrology, Anaesthesiology and Geriatric Sciences, Sapienza University of Rome, 00161 Rome, Italy. camilla.calvieri@uniroma1.it.

Antioxidants (Basel, Switzerland)
|July 5, 2018
PubMed

Insights

Oxidative stress and platelet activation are closely linked in ST-elevation myocardial infarction (STEMI) patients, contributing to coronary thrombus formation and burden. This study highlights their interplay in STEMI pathogenesis.

Area of Science:

  • Cardiovascular Medicine
  • Biochemistry
  • Hematology

Background:

  • Platelet activation and oxidative stress are implicated in coronary thrombus formation and burden in ST-elevation myocardial infarction (STEMI).
  • The precise interplay between oxidative stress and platelet activation in STEMI remains incompletely understood.

Purpose of the Study:

  • To investigate the relationship between oxidative stress markers and platelet activation markers in STEMI patients.
  • To explore the role of oxidative stress in promoting thrombus formation and growth in STEMI.

Main Methods:

  • Assessed oxidative stress using NADPH oxidase isoform 2 activity (sNox2-dp) and oxidized low-density lipoproteins (oxLDLs).
  • Measured platelet activation markers including soluble CD40 Ligand (sCD40L) and soluble P-selectin (sP-selectin).
  • Analyzed coronary thrombi, blood waste, and peripheral blood samples from STEMI patients and compared with stable angina (SA) patients.

Main Results:

  • STEMI patients exhibited significantly higher levels of sNox2-dp, oxLDLs, sCD40L, and sP-selectin in thrombi and blood waste compared to SA patients.
  • A direct correlation was observed between markers of oxidative stress and platelet activation within STEMI thrombi.
  • Increased oxidative stress and platelet activation markers correlated with higher thrombus burden in STEMI patients.

Conclusions:

  • A strong association exists between oxidative stress and platelet activation in the intracoronary environment of STEMI patients.
  • Oxidative stress appears to play a significant role in promoting coronary thrombus formation and progression in STEMI.
Abstract

Keywords:
STEMIThrombolysis in Myocardial Infarction (TIMI) thrombus scorecoronary thrombusoxidative stressplatelet activation

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