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Related Experiment Video

Updated: Feb 8, 2026

Macrophage Cholesterol Depletion and Its Effect on the Phagocytosis of Cryptococcus neoformans

Macrophage Cholesterol Depletion and Its Effect on the Phagocytosis of Cryptococcus neoformans

Published on: December 19, 2014

Present and Future Therapy of Cryptococcus Infections.

Ahmad Mourad¹, John R Perfect²

¹Division of Infectious Diseases, Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA. ahmad.mourad@duke.edu.

Journal of Fungi (Basel, Switzerland)

|July 5, 2018

Summary

Cryptococcal infections cause high mortality in immunocompromised patients. New strategies focus on shorter treatments with accessible antifungals like fluconazole to improve outcomes, especially in resource-limited settings.

Keywords:

Cryptococcus antifungal agents antifungal therapy cryptococcal meningitis cryptococcosis

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Immunometabolic Circuits in Infection for Advancing Host Directed Therapies

Immunometabolic Circuits in Infection for Advancing Host Directed Therapies

Published on: September 13, 2024

Area of Science:

Mycology
Infectious Diseases
Clinical Pharmacology

Background:

Cryptococcal infections significantly impact immunocompromised individuals, including those with HIV and organ transplants, leading to high morbidity and mortality.
Current therapeutic options present challenges, particularly in resource-limited settings, necessitating improved management strategies.
Antifungal resistance is an emerging threat complicating treatment efficacy.

Purpose of the Study:

To review current and future management principles for cryptococcal infections.
To explore novel antifungal agents and treatment strategies.
To address challenges in resource-limited settings and emerging antifungal resistance.

Main Methods:

Literature review of clinical trials and research on cryptococcal infection management.
Analysis of current therapeutic guidelines and antifungal drug development.
Discussion of emerging techniques and future directions in patient care.

Main Results:

Focus on reducing therapy duration and utilizing cost-effective antifungals like fluconazole.
Identification of antifungal resistance as a significant challenge requiring new agent development.
Exploration of strategies to mitigate adverse reactions and improve treatment accessibility.

Conclusions:

Optimizing cryptococcal infection management requires innovative approaches, including shorter treatment regimens and accessible antifungals.
Addressing antifungal resistance and developing new therapeutic agents are crucial for improving patient outcomes.
Future research should prioritize cost-effective and evidence-based strategies for diverse clinical settings.