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Hypertriglyceridemia is associated with impaired fasting glucose in normal-weight children

Luis E Simental-Mendía1, Martha Rodríguez-Morán1, Celia Aradillas-García2

  • 1Unidad de Investigación Biomédica, Delegación Durango, Instituto Mexicano del Seguro Social, Durango, Mexico.

Pediatric Research
|July 5, 2018
PubMed

Insights

Elevated triglycerides are linked to impaired fasting glucose in older children (10-15 years). This association was not found in younger children (7-9 years) in this study.

Area of Science:

  • Pediatric Endocrinology
  • Metabolic Health
  • Cardiovascular Risk Factors

Background:

  • Adult studies suggest high triglycerides precede glucose issues.
  • This hypothesis remained untested in pediatric populations.
  • Research is needed to understand early metabolic disturbances in children.

Purpose of the Study:

  • To investigate the association between hypertriglyceridemia and impaired fasting glucose (IFG) in normal-weight children.
  • To determine if triglyceride levels are an early indicator of glucose metabolism disturbances in pediatric populations.
  • To explore age-specific differences in this association.

Main Methods:

  • Cross-sectional study of 1453 normal-weight children aged 7-15 years.
  • Defined hypertriglyceridemia based on age-specific triglyceride levels (≥100 mg/dL for 7-9 yrs, ≥130 mg/dL for 10-15 yrs).
  • Defined impaired fasting glucose (IFG) by fasting plasma glucose levels (≥100 and <126 mg/dL).
  • Logistic regression analysis adjusted for age, gender, BMI, waist circumference, and insulin levels.

Main Results:

  • Prevalence of hypertriglyceridemia was 11.8% and IFG was 11.2% in the study population.
  • Hypertriglyceridemia was significantly associated with IFG in children aged 10-15 years (OR=1.67, p=0.04).
  • No significant association between hypertriglyceridemia and IFG was observed in children aged 7-9 years (OR=1.48, p=0.55).

Conclusions:

  • Hypertriglyceridemia is a significant risk factor for impaired fasting glucose in normal-weight children aged 10-15 years.
  • The association between high triglycerides and IFG is age-dependent in children.
  • Findings suggest monitoring triglyceride levels in older children may help identify those at risk for glucose metabolic disturbances.
Abstract

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