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Neuroticism and suicide in a general population cohort: results from the UK Biobank Project
Evyn M Peters1, Ann John2, Rudy Bowen1
1Department of Psychiatry, University of Saskatchewan, Saskatoon, SK, Canada.
Background:
Neuroticism has often been linked to suicidal thoughts and behaviour.
Aims:
To examine whether neuroticism is associated with suicide deaths after adjusting for known risks.
Method:
UK Biobank participants (n = 389 365) were assessed for neuroticism as well as social, demographic and health-related variables at study entry and followed for up to 10 years. Suicide risk was modelled using Cox regression stratified by gender.
Results:
Neuroticism increased the risk of suicide in both men (hazard ratio (HR) = 1.15, 95% CI 1.09-1.22) and women (HR = 1.16, 95% CI 1.06-1.27). In a subsample who were assessed for mood disorders, neuroticism remained a significant predictor for women (HR 1.25, 95% CI 1.03-1.51) but not for men.
Conclusions:
Screening and therapeutic interventions for neuroticism may be important for early suicide prevention.
Declaration Of Interest:
None.
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