Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Lifecycle of Erythrocytes01:22

Lifecycle of Erythrocytes

5.3K
Erythrocytes, also known as red blood cells, constantly move through blood capillaries. As a result, they damage their plasma membrane due to the continuous friction. Typically, after 100 to 120 days, erythrocytes become rigid and fragile as they wear out. As they pass through small vessels in the spleen and liver, they can get trapped and break apart into fragments.
The resident phagocytic macrophages deal with these damaged cells by engulfing them and separating their globin and heme groups....
5.3K
Disorders of Erythrocytes01:27

Disorders of Erythrocytes

2.3K
Disorders of erythrocytes, or red blood cells (RBCs), include a range of conditions affecting their number, shape, or function.
Erythrocyte disorders can be broadly categorized into two main types: anemic and polycythemic conditions.
A low oxygen-carrying capacity of the blood due to the loss, lower production, or destruction of erythrocytes is termed anemia. Hemorrhagic anemia, for example, occurs when bleeding from an external wound or internal ulcer reduces erythrocyte counts.
On the other...
2.3K
Structure and Function of Erythrocytes01:29

Structure and Function of Erythrocytes

6.0K
There are between 4.2 and 6 million erythrocytes, also known as red blood cells, in every microliter of blood. These cells are small, flattened biconcave discs with centers that are depressed.
The erythrocyte plasma membrane is associated with proteins such as spectrin, which forms a flexible cytoplasmic meshwork. This meshwork allows erythrocytes to twist, turn, become cup-shaped, and regain their biconcave shape as they pass through narrow capillaries. Additionally, erythrocytes can form...
6.0K
What is Genetic Engineering?00:49

What is Genetic Engineering?

80.3K
Overview
80.3K
Heat Engines01:10

Heat Engines

3.7K
A heat engine is a device used to extract heat from a source and then convert it into mechanical work used for various applications. For example, a steam engine on an old-style train can produce the work needed for driving the train.
Whenever we consider heat engines (and associated devices such as refrigerators and heat pumps), we do not use the standard sign convention for heat and work. For convenience, we assume that the symbols Qh, Qc, and W represent only the amounts of heat transferred...
3.7K
Introduction to Membrane Proteins01:16

Introduction to Membrane Proteins

81.3K
The cell membrane, or plasma membrane, is an ever-changing landscape. It is described as a fluid mosaic where various macromolecules are embedded in the phospholipid bilayer. Among the macromolecules are proteins. The protein content varies across cell types. For example, mitochondrial inner membranes contain ~76% protein content, while myelin contains ~18% protein content. Individual cells contain many types of membrane proteins—red blood cells contain over 50—and different cell...
81.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Hemocompatibility of 3D-Printed ABS for Blood-Contacting Applications.

ACS biomaterials science & engineering·2026
Same author

Correlating polymer solution and membrane fabrication with morphological and permeation properties of cellulose acetate ultrafiltration membranes.

Carbohydrate polymers·2026
Same author

The Effect of Independent Humidity Control on Aerosol Drug Delivery During Adult Invasive Mechanical Ventilation.

Respiratory care·2026
Same author

Incorporation of NU-1000 into cellulose acetate membranes with preserved indoxyl sulfate adsorption.

Journal of materials chemistry. B·2026
Same author

Porcine Corneal Models as Translational Platforms for Innovative Therapies: Current Insights and Future Directions.

Journal of functional biomaterials·2025
Same author

What Determines the Breakup Length of a Jet?

Physical review letters·2025

Related Experiment Video

Updated: Feb 8, 2026

Micro-scale Engineering for Cell Biology
04:42

Micro-scale Engineering for Cell Biology

Published on: October 1, 2007

5.2K

Erythrocyte fouling on micro-engineered membranes.

Levy I Amar1, Daniela Guisado2, Monica Faria2

  • 1Department of Biomedical Engineering, Columbia University, New York, NY, 10027, USA. Lia2103@columbia.edu.

Biomedical Microdevices
|July 5, 2018
PubMed
Summary

Red blood cell deformability is key to crossflow microfiltration. Unique erythrocyte behavior on the membrane enables stable plasma separation for biomedical devices.

Keywords:
BloodCross-flowErythrocytesFoulingMicrofiltration modelMicrofluidicsMicrosieveNanoporesPhotolithographySieve

More Related Videos

Microfluidic Buffer Exchange for Interference-free Micro/Nanoparticle Cell Engineering
10:27

Microfluidic Buffer Exchange for Interference-free Micro/Nanoparticle Cell Engineering

Published on: July 10, 2016

9.6K
Erythrocyte Sedimentation Rate: A Physics-Driven Characterization in a Medical Context
08:07

Erythrocyte Sedimentation Rate: A Physics-Driven Characterization in a Medical Context

Published on: March 24, 2023

4.0K

Related Experiment Videos

Last Updated: Feb 8, 2026

Micro-scale Engineering for Cell Biology
04:42

Micro-scale Engineering for Cell Biology

Published on: October 1, 2007

5.2K
Microfluidic Buffer Exchange for Interference-free Micro/Nanoparticle Cell Engineering
10:27

Microfluidic Buffer Exchange for Interference-free Micro/Nanoparticle Cell Engineering

Published on: July 10, 2016

9.6K
Erythrocyte Sedimentation Rate: A Physics-Driven Characterization in a Medical Context
08:07

Erythrocyte Sedimentation Rate: A Physics-Driven Characterization in a Medical Context

Published on: March 24, 2023

4.0K

Area of Science:

  • Biomedical Engineering
  • Microfluidics
  • Biophysics

Background:

  • Crossflow microfiltration of blood plasma is crucial for biomedical applications.
  • Wearable water removal devices are under development.

Purpose of the Study:

  • To correlate filtration rates, transmembrane pressures (TMP), and shear rates.
  • To observe erythrocyte behavior during microfiltration.
  • To understand filtration resistance mechanisms.

Main Methods:

  • Microfiltration experiments using photolithographically-produced porous semiconductor membranes.
  • Observation of erythrocyte behavior at the filtering surface.
  • Scanning electron microscopy of filtered membranes.

Main Results:

  • Erythrocyte deformability significantly impacts filtration resistance.
  • At high TMP, erythrocytes form incomplete monolayers, enabling sustainable filtration.
  • Filtration flux depends on wall shear rate, with weak dependence on erythrocyte concentration.

Conclusions:

  • Erythrocyte behavior, specifically their deformability and self-assembly, is a critical factor in microfiltration performance.
  • An unrecognized mechanism supports stable filtration despite cell layers.
  • Findings advance the development of microfiltration devices for biomedical use.