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Updated: Feb 8, 2026

In Vivo Real-Time Study of Drug Effects on Carotid Blood Flow in the Ovine Fetus
Published on: April 28, 2023
An effect of maternal nifedipine therapy on fetoplacental blood flow: a prospective study
Ahmet Namazov1, Leonti Grin2, Resul Karakus3
1Department of Obstetrics and Gynecology, Barzilai University Medical Center, Ben-Gurion University of Negev, Faculty of Health Sciences, HaHistadrut street 2, Ashkelon, Israel. enamazov@gmail.com.
Purpose:
The aim of this study is to assess the effects of maternal nifedipine administration on placental and fetal blood flow.
Methods:
A total of 29 patients with preterm labor diagnosis admitted to the tertiary care center, Zeynep Kamil Hospital, were evaluated. Before and 24-48 h after administration of oral nifedipine, Doppler ultrasound scan was carried out to measure fetal middle cerebral artery, ductus venosus, umbilical artery, and maternal uterine artery blood flow.
Results:
After 24 and 48 h of therapy, there were no changes in mean PI and RI in the umbilical arteries and ductus venosus (p > 0.05). Fetal middle cerebral artery and maternal uterine artery PI and RI values showed a significant reduction 24-48 h after oral nifedipine therapy (p < 0.05).
Conclusions:
Our study showed that 24 and 48 h after oral nifedipine therapy, there is a significant increase in fetal MCA and maternal uterine artery blood flow, while fetal umbilical artery and ductus venosus Doppler values do not change.
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