Antihypertensive effect of azilsartan versus olmesartan in patients with essential hypertension: a meta-analysis

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Di Zhao1, Hui Liu2, Pingshuan Dong3

  • 1Division of Hypertension, The First Affiliated Hospital, and College of Clinical Medicine of Henan University of Science and Technology, 24 Jinghua Avenue, Luoyang, 471003, China. emaildizhao@163.com.

Irish Journal of Medical Science
|July 5, 2018
PubMed

Insights

Azilsartan demonstrated a greater reduction in systolic blood pressure compared to olmesartan in patients with essential hypertension. This meta-analysis highlights azilsartan

Area of Science:

  • Cardiology
  • Pharmacology
  • Clinical Trials

Background:

  • Essential hypertension is a widespread condition requiring effective antihypertensive treatments.
  • Azilsartan and olmesartan are both angiotensin II receptor blockers (ARBs) used for hypertension management.
  • Previous studies comparing azilsartan and olmesartan have yielded inconsistent results regarding their efficacy.

Purpose of the Study:

  • To conduct a meta-analysis comparing the antihypertensive effects of azilsartan versus olmesartan.
  • To determine the comparative efficacy of azilsartan and olmesartan in reducing blood pressure in patients with essential hypertension.

Main Methods:

  • A systematic literature search was performed across PubMed, Web of Science, and Cochrane Central.
  • Included were all published randomized controlled trials comparing azilsartan and olmesartan in essential hypertension patients.
  • Data from five trials involving 1402 patients were analyzed.

Main Results:

  • Azilsartan showed a statistically significant greater reduction in office systolic blood pressure compared to olmesartan (WMD -2.15 mm Hg, p < 0.01).
  • No significant difference was observed in the reduction of office diastolic blood pressure between the two drugs (WMD -0.99 mm Hg, p > 0.05).
  • Even at the same dosage, azilsartan demonstrated superior systolic blood pressure reduction (WMD -2.24 mm Hg, p < 0.05), with no significant diastolic difference.

Conclusions:

  • This meta-analysis provides evidence that azilsartan is more effective than olmesartan in reducing systolic blood pressure in essential hypertension.
  • The findings underscore the importance of well-designed randomized controlled trials for evaluating ARBs in clinical practice.
  • Further research may explore long-term outcomes and differential effects of these ARBs.
Abstract

Keywords:
AzilsartanEssential hypertensionMeta-analysisOlmesartan

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