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Cardiovascular Autonomic Dysfunction in Patients with Cancer
Ben G T Coumbe1, John D Groarke2,3
1School of Clinical Medicine, University College London Medical School, Gower Street, London, WC1E 6BT, UK.
Current Cardiology Reports
|July 5, 2018
Summary
Autonomic dysfunction (AD) is common in cancer patients, increasing cardiovascular risks and impacting quality of life. Understanding and treating AD is crucial for improving outcomes in cancer survivors.
Area of Science:
- Cardiology
- Oncology
- Neuroscience
Background:
- Autonomic dysfunction (AD) is increasingly recognized in cancer patients and survivors.
- Risk factors include cancer itself, treatments like chemotherapy and radiation, and comorbidities.
- AD prevalence may be higher in cancer survivors than in cancer-free individuals.
Purpose of the Study:
- To review the assessment, causes, and clinical significance of AD in cancer patients.
- To explore potential therapeutic and research avenues for managing AD in this population.
Main Methods:
- This is a review article, synthesizing existing literature.
- It explores data on AD prevalence, risk factors, and clinical implications in cancer patients and survivors.
Main Results:
- AD is prevalent across the cancer continuum and linked to adverse cardiovascular outcomes.
- Markers of AD, such as elevated heart rate and reduced heart rate variability, correlate with shorter survival.
- AD contributes to cancer-related fatigue and exercise limitation.
Conclusions:
- The impact of AD on morbidity and mortality in cancer survivors is significant but often overlooked.
- Further research is needed to understand cancer treatment-specific autonomic injury.
- Investigating interventions for sympathovagal imbalance in cancer survivors is essential.
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