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Related Experiment Video

Updated: Feb 8, 2026

Advanced Animal Model of Colorectal Metastasis in Liver: Imaging Techniques and Properties of Metastatic Clones
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Editorial: Therapy-induced metastasis.

Olga A Martin1, Robin L Anderson2,3

  • 1Peter MacCallum Cancer Centre, Melbourne, VIC, Australia.

Clinical & Experimental Metastasis
|July 5, 2018
PubMed
Summary

Cancer therapies like chemotherapy and radiotherapy may increase circulating tumor cells (CTCs), potentially worsening metastasis. This special issue explores how common cancer treatments can inadvertently promote tumor progression and recurrence.

Keywords:
Cancer therapyChemotherapyMetastasisRadiotherapySurgery

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Area of Science:

  • Oncology
  • Cancer Biology
  • Translational Research

Background:

  • A review highlighted that major cancer therapies might increase circulating tumor cells (CTCs) and metastasis risk.
  • This led to a special issue investigating therapy-induced tumor progression.

Discussion:

  • Ten research groups present findings on biological processes and clinical procedures enhancing metastasis or recurrence.
  • Evidence suggests common cancer treatments, including radiotherapy, chemotherapy, biopsies, surgery, and anesthesia, can promote tumor progression.

Key Insights:

  • Cancer treatments can inadvertently mobilize circulating tumor cells (CTCs).
  • Therapy-induced tumor progression is a significant concern across various treatment modalities.
  • Radiotherapy, chemotherapy, surgical procedures, biopsies, and anesthesia are implicated.

Outlook:

  • Further research is needed to understand and mitigate therapy-induced tumor progression.
  • Developing strategies to prevent treatment-related metastasis and recurrence is crucial.
  • This compilation provides a comprehensive overview for researchers and clinicians in oncology.