Related Experiment Video
Updated: Feb 8, 2026

The Multiple Sclerosis Performance Test MSPT: An iPad-Based Disability Assessment Tool
Published on: June 30, 2014
Clinical Application of 2017 McDonald Diagnostic Criteria for Multiple Sclerosis
Vittorio Mantero1, Lucia Abate2, Roberto Balgera3
1Neurological Unit, MS Centre, A. Manzoni Hospital-ASST Lecco, Lecco, Italy. vittorio.mantero@hotmail.com.
Background And Purpose:
McDonald criteria for multiple sclerosis diagnosis have been revised over the years, diagnostic procedures have been simplified and earlier diagnosis facilitated. The new 2017 revision introduces other important changes, with a further simplification for the diagnosis. Oligoclonal bands reassume a more relevant role in the workup.
Methods:
We describe 3 typical cases of patients admitted for clinically isolated syndrome and illustrate how the application of the new criteria can change the diagnostic approach with respect to the previous criteria.
Results:
In two of the three cases a diagnosis of multiple sclerosis is now possible.
Conclusions:
The new 2017 Multiple Sclerosis criteria may have an important impact in clinical practice with an earlier treatment to avoid the risk of disease dissemination. Their application requires a careful assessment to avoid misdiagnosis and mistreatments.
Related Concept Videos
Pericarditis II: Clinical Features and Diagnostic Tests
Atherosclerosis II: Clinical Manifestations and Diagnostic Tests
Aneurysm II: Clinical Manifestations and Diagnostic Studies
Myocarditis II: Clinical Features and Diagnostic Tests
Mitral Regurgitation II: Clinical Features and Diagnostic Tests
Hypertension III: Clinical Manifestations and Diagnostic Studies

