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Related Experiment Videos

Inhalative provocation test. When is it positive?

H Matthys

    Scandinavian Journal of Respiratory Diseases. Supplementum
    |January 1, 1979
    PubMed
    Summary
    This summary is machine-generated.

    Asthmatic patients

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    Area of Science:

    • Pulmonary medicine
    • Respiratory physiology

    Background:

    • Asthma management involves assessing airway hyperresponsiveness.
    • Whole body plethysmography is a key diagnostic tool.
    • Differentiating allergic and non-allergic airway responses is crucial.

    Purpose of the Study:

    • To establish reference ranges for airway resistance (R) and R/Rref quotient.
    • To evaluate non-allergic provocation responses in asthmatic patients.
    • To guide the safe and effective use of inhalative provocation tests.

    Main Methods:

    • Whole body plethysmography was used to measure airway resistance (R) and reference resistance (Rref).
    • Patients underwent unspecific inhalative provocation.
    • Initial R/Rref quotients were categorized (<2 and 2-5).

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    Main Results:

    • Patients with initial R/Rref < 2 showed non-allergic reactions not exceeding 2.7.
    • Patients with initial R/Rref between 2 and 5 reached R/Rref values up to 8.5.
    • Higher initial R/Rref values correlated with greater non-allergic responses.

    Conclusions:

    • Recommends performing provocation tests only in patients with initial R/Rref < 2.
    • This threshold helps distinguish allergic from non-allergic reactions.
    • Avoids potentially harmful allergen-induced bronchospasm in susceptible individuals.