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Manipulation and Analysis of Cell Cycle-Dependent Processes in Budding Yeast
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Manipulation and Analysis of Cell Cycle-Dependent Processes in Budding Yeast

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Multiple inputs ensure yeast cell size homeostasis during cell cycle progression.

Cecilia Garmendia-Torres1,2,3,4, Olivier Tassy1,2,3,4, Audrey Matifas1,2,3,4

  • 1Institut de Génétique et de Biologie Moléculaire et Cellulaire, Illkirch, France.

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|July 5, 2018
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Summary

Cell size homeostasis in budding yeast is maintained by a G2/M mechanism controlling bud size and preventing premature anaphase. This size control is an emergent property from integrated growth and division mechanisms, not solely G1-dependent.

Keywords:
S. cerevisiaecell biologycell cyclecomputational biologymicrofluidicssize controlsystems biology

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Area of Science:

  • Cell Biology
  • Molecular Biology
  • Genetics

Background:

  • Cell growth coordination with division is crucial for cell function.
  • While G1 phase cell size control mechanisms are known in budding yeast, the overall cell size homeostasis mechanism remains unclear.

Purpose of the Study:

  • To investigate the mechanisms underlying cell size homeostasis in budding yeast.
  • To identify the cell cycle phase(s) and molecular players involved in maintaining cell size stability.

Main Methods:

  • Development of a novel technique for accurate cell cycle monitoring via histone level quantification in individual cells.
  • Analysis of cell cycle progression and size control in wild-type and mutant budding yeast strains.

Main Results:

  • A mechanism controlling bud size in the G2/M phase was identified, preventing premature anaphase onset and regulating size variability.
  • Mutants with altered cyclin B-Cdk regulation exhibited significant cell size variability.
  • Cell size homeostasis was not impaired in most G1 mutants, suggesting a broader regulatory network.

Conclusions:

  • Cell size homeostasis is not solely regulated by G1-specific mechanisms.
  • A G2/M phase mechanism plays a role in controlling bud size and overall cell size variability.
  • Size homeostasis likely emerges from the integration of multiple mechanisms coordinating cell growth and division.