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Updated: Feb 8, 2026

Animal Model of Implant-Associated Infections in Mice
Published on: June 27, 2025
INFLUENCE OF SPLENIC IMPLANTS IN THE SUBCUTANEOUS TISSUE ON ASPLENIC ANIMALS SURVIVAL
Renan Kleber Costa Teixeira1, Laryssa de Aquino Santiago1, Yan de Assis Sasaki1
1Laboratório de Cirurgia Experimental da Faculdade de Medicina da Universidade Estadual do Pará - UEPA, Belém, PA.
Background:
The best site for splenic implant was not defined, mainly evaluating the functionality of the implant.
Aim:
To evaluate the effects of autogenous splenic implantation on the subcutaneous tissue in the survival of splenectomized rats.
Method:
Twenty-one randomly assigned rats were studied in three groups (n=7): group 1 - manipulation of the abdominal cavity and preservation of the spleen; group 2 - total splenectomy; group 3 - splenectomy and implant of the tissue removed in the subcutaneous. The animals were followed for 90 days postoperatively.
Results:
There was a higher mortality in groups 2 (p=0.0072) and 3 (p=0.0172) in relation to group 1. There was no difference between groups 2 and 3 (p=0.9817).
Conclusion:
The splenic implant in the subcutaneous is ineffective in the survival of rats submitted to splenectomy.
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