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Published on: October 27, 2023
Clinical and laboratorial features of oral candidiasis in HIV-positive patients
Regiane Nogueira Spalanzani1, Karine Mattos2, Luiza Inahe Marques1
1Curso de Farmácia, Universidade Federal de Mato Grosso do Sul, Campo Grande, MS, Brasil.
Introduction:
We describe the clinical and laboratorial features of oral candidiasis in 66 HIV-positive patients.
Methods:
Polymerase chain reaction-based techniques were performed for differentiation of Candida spp. isolated from patients at a public teaching hospital in Midwest Brazil.
Results:
Oral lesions, mainly pseudomembranous, were significantly related to higher levels of immunosuppression. Of 45 Candida isolates, 66.7% were C. albicans. Most of the isolates were susceptible to the antifungal drugs tested.
Conclusions:
Oral lesions were associated with higher immunosuppression levels. Lower susceptibility to antifungals by non-albicans isolates supports the importance of surveillance studies using susceptibility tests to aid in the treatment.
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