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Subcutaneous Infection of Methicillin Resistant Staphylococcus Aureus MRSA
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Subcutaneous Infection of Methicillin Resistant Staphylococcus Aureus MRSA

Published on: February 9, 2011

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Coexistence of virulence genes in methicillin-resistant Staphylococcus aureus clinical isolates

Adriana Medianeira Rossato1, Keli Cristine Reiter1, Pedro Alves d'Azevedo1

  • 1Laboratório de Cocos Gram-positivos, Universidade Federal de Ciências da Saúde de Porto Alegre, Porto Alegre, RS, Brasil.

Revista Da Sociedade Brasileira De Medicina Tropical
|July 5, 2018
PubMed
Abstract

Insights

Methicillin-resistant Staphylococcus aureus (MRSA) strains frequently carry multiple virulence genes. This suggests common horizontal gene transfer, contributing to the pathogen

Area of Science:

  • Microbiology
  • Genetics
  • Infectious Diseases

Background:

  • Staphylococcus aureus exhibits pathogenic versatility due to virulence genes like enterotoxins and hemolysins.
  • Understanding the genetic makeup of MRSA is crucial for infection control.

Purpose of the Study:

  • To detect and analyze the prevalence of specific virulence genes in nosocomial MRSA strains.
  • To investigate the coexistence patterns of virulence genes within MRSA isolates.

Main Methods:

  • Polymerase Chain Reaction (PCR) was employed to identify virulence genes.
  • 177 nosocomial MRSA strains from Porto Alegre, Brazil, were analyzed.

Main Results:

  • High prevalence rates were observed for hemolysin genes (hla, 87.6%; hld, 90.4%).
  • The toxic shock syndrome toxin (tst) gene was present in 27.7% of strains, and the Panton-Valentine leukocidin (pvl) gene in 18.6%.
  • Frequent co-occurrence of tst with pvl (40.7%) and hla with hld (26.6%) was noted.

Conclusions:

  • The frequent coexistence of multiple virulence genes indicates common horizontal gene transfer in S. aureus.
  • This genetic exchange likely contributes to the adaptability and pathogenicity of MRSA.

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