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Author Spotlight: Development and Evaluation of a Compound Acne Rodent Model Using C. acnes and Oleic Acid
Published on: November 1, 2024
Codelivery of benzoyl peroxide & adapalene using modified liposomal gel for improved acne therapy
Sanyog Jain1, Dnyaneshwar P Kale1, Rajan Swami1
1Department of Pharmaceutics, National, Centre for Pharmaceutical Nanotechnology, Institute of Pharmaceutical Education & Research (NIPER), Sector 67, S.A.S. Nagar (Mohali) Punjab, 160062, India.
Aim:
Current study investigates therapeutic efficacy and tolerability of benzoyl peroxide (BPO)- and adapalene (AD)-loaded modified liposomal gel (BPO-AD-mLipo gel) for improved acne therapy.
Materials & Method:
BPO-AD-mLipo were optimized and loaded in Carbopol gel. Both BPO-AD-mLipo and BPO-AD-mLipo-gel were extensively characterized for different quality attributes. Ex vivo dermal bioavailability, dermal distribution, in vivo anti-acne efficacy and skin irritation studies were performed and compared with marketed formulation (Epiduo®, Galderma Laboratories LP, TX, USA).
Results:
BPO-AD-mLipo illustrated size 256.4 ± 9.3 nm with polydispersity index ∼ 0.2. Significantly enhanced dermal bioavailability (AD-2.1, 5.4; BPO-3.0, 7.83-fold) and reduction in skin irritation and papule density in animal model were observed with BPO-AD-mLipo-gel as compared with free drugs and Epiduo, respectively.
Conclusion:
BPO-AD-mLipo gel provides effective and safer alternative approach for codelivery of anti-acne drugs.
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