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Related Experiment Video

Updated: Feb 8, 2026

Procoagulant Platelet Characterization by Measuring Phosphatidylserine Exposure and Microvesicle Release from Human Purified Platelets
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Platelet Counts during Pregnancy.

Jessica A Reese1, Jennifer D Peck1, David R Deschamps1

  • 1From the Department of Biostatistics and Epidemiology, College of Public Health (J.A.R., J.D.P., D.R.T., S.K.V., J.N.G.), the Hematology-Oncology Section, Department of Medicine, College of Medicine (J.A.R., J.N.G.), and the Maternal-Fetal Medicine Section, Department of Obstetrics and Gynecology, College of Medicine (D.R.D., J.J.M., E.J.K.), University of Oklahoma Health Sciences Center, Oklahoma City.

The New England Journal of Medicine
|July 5, 2018
PubMed
Summary
This summary is machine-generated.

Platelet counts naturally decrease during pregnancy, with most uncomplicated cases remaining above 100,000/mm³. Seek other causes for counts below 100,000/mm³ in pregnant individuals.

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Area of Science:

  • Obstetrics and Gynecology
  • Hematology
  • Maternal-Fetal Medicine

Background:

  • Gestational thrombocytopenia is defined as platelet counts <150,000/mm³ in pregnancy without an alternative cause.
  • Platelet counts can be lower in pregnancies with complications.
  • The precise occurrence and severity of thrombocytopenia throughout pregnancy remain undefined.

Purpose of the Study:

  • To evaluate platelet counts throughout pregnancy in women delivering at a major medical center.
  • To compare these counts with those of nonpregnant women.
  • To define the incidence and severity of thrombocytopenia during pregnancy and its complications.

Main Methods:

  • Retrospective analysis of platelet counts from 7351 women delivering between 2011-2014.
  • Comparison with platelet counts from 8885 nonpregnant women in NHANES (1999-2012).
  • Stratification of pregnant women into uncomplicated pregnancies, pregnancies with complications, and those with pre-existing thrombocytopenia disorders.

Main Results:

  • Mean platelet counts decreased significantly from the first trimester in uncomplicated pregnancies (251,000/mm³) compared to nonpregnant women (273,000/mm³).
  • At delivery, 9.9% of uncomplicated pregnancies had <150,000/mm³ platelets; only 1.0% had <100,000/mm³.
  • Pregnancy complications were associated with a higher incidence of thrombocytopenia (<150,000/mm³).

Conclusions:

  • Platelet counts progressively decrease during pregnancy, starting in the first trimester.
  • Platelet counts below 100,000/mm³ warrant investigation for causes beyond typical pregnancy-related changes.
  • This study provides a clearer definition of thrombocytopenia occurrence and severity throughout pregnancy.