Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

10.0K
In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
10.0K
lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

3.7K
3.7K
siRNA - Small Interfering RNAs02:30

siRNA - Small Interfering RNAs

18.7K
Small interfering RNAs, or siRNAs, are short regulatory RNA molecules that can silence genes post-transcriptionally, as well as the transcriptional level in some cases. siRNAs are important for protecting cells against viral infections and silencing transposable genetic elements.
In the cytoplasm, siRNA is processed from a double-stranded RNA, which comes from either endogenous DNA transcription or exogenous sources like a virus. This double-stranded RNA is then cleaved by the...
18.7K
piRNA - Piwi-interacting RNAs02:57

piRNA - Piwi-interacting RNAs

7.7K
PIWI-interacting RNAs, or piRNAs, are the most abundant short non-coding RNAs. More than 20,000 genes have been found in humans that code for piRNAs while only 2000 genes have been found for miRNAs. piRNAs can act at the transcriptional and post-transcriptional levels and have a vital role in silencing transposable elements present in germ cells. They are also involved in epigenetic silencing and activation. Previously, they were thought to function only in germ cells but new evidence suggests...
7.7K
Small interfering RNAs (siRNA)02:30

Small interfering RNAs (siRNA)

4.6K
4.6K
Inflammatory Bowel Disease II: Crohn's Disease01:30

Inflammatory Bowel Disease II: Crohn's Disease

1.1K
Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
1.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Properties of Stereopure Phosphorothioate Groups in RNA-PROTACs.

Chimia·2026
Same author

Psychiatric comorbidities of posttraumatic stress disorder among adolescent refugees in Uganda: A latent class analysis of patterns and covariates.

Comprehensive psychiatry·2026
Same author

Self-Help Plus for refugee mothers in Rhino Refugee Settlement, Uganda (SEED): study protocol for a cluster-randomized controlled trial assessing intergenerational effects on preschool-aged children.

Trials·2026
Same author

Examining suicidality and associated risk factors among refugee children and adolescents in Uganda.

BMC psychiatry·2025
Same author

Combining mental health and climate-smart agricultural interventions to improve food security in humanitarian settings: study protocol for the THRIVE cluster-randomized controlled trial with mothers in Nakivale refugee settlement, Uganda.

Trials·2025
Same author

Health Educators and Academic Leaders: A Developmental, Principles-Focused Program Evaluation Approach for Aspiring Clinician Educators in Graduate Medical Education.

Journal of graduate medical education·2025

Related Experiment Video

Updated: Feb 8, 2026

Overexpressing Long Noncoding RNAs Using Gene-activating CRISPR
13:04

Overexpressing Long Noncoding RNAs Using Gene-activating CRISPR

Published on: March 1, 2019

9.3K

Noncoding RNAs in disease.

Evangelia Lekka1, Jonathan Hall1

  • 1Department of Chemistry and Applied Biosciences, Institute of Pharmaceutical Sciences, ETH Zürich, Switzerland.

FEBS Letters
|July 5, 2018
PubMed
Summary

Noncoding RNAs, including microRNAs (miRNAs) and long noncoding RNAs, are key regulators in biology and disease. Aberrant expression of these RNAs is linked to cancer, cardiovascular, and neurological disorders, offering new therapeutic targets.

Area of Science:

  • Molecular Biology
  • Genetics
  • Biochemistry

Background:

  • Noncoding RNAs are crucial regulators of biological processes.
  • Altered noncoding RNA expression is associated with various human diseases.
  • Previous reviews often focused on specific microRNAs or diseases.

Purpose of the Study:

  • To highlight the broad involvement of noncoding RNAs in disease pathophysiology.
  • To showcase the roles of microRNAs and long noncoding RNAs in specific disease categories.
  • To underscore the therapeutic potential stemming from noncoding RNA research.

Main Methods:

  • Review of selected studies on noncoding RNAs.
  • Focus on microRNAs (miRNAs) and long noncoding RNAs (lncRNAs).
  • Examination of roles in cancer, cardiovascular, and neurological disorders.
Keywords:
long noncoding RNAmicroRNAnoncoding RNA

More Related Videos

Isolation of Small Noncoding RNAs from Human Serum
06:44

Isolation of Small Noncoding RNAs from Human Serum

Published on: June 19, 2014

18.6K
Author Spotlight: A Computational Pipeline for Analyzing Chimeric Noncoding RNA-Target RNA Interactions in High-Throughput Sequencing Data
07:35

Author Spotlight: A Computational Pipeline for Analyzing Chimeric Noncoding RNA-Target RNA Interactions in High-Throughput Sequencing Data

Published on: December 1, 2023

1.2K

Related Experiment Videos

Last Updated: Feb 8, 2026

Overexpressing Long Noncoding RNAs Using Gene-activating CRISPR
13:04

Overexpressing Long Noncoding RNAs Using Gene-activating CRISPR

Published on: March 1, 2019

9.3K
Isolation of Small Noncoding RNAs from Human Serum
06:44

Isolation of Small Noncoding RNAs from Human Serum

Published on: June 19, 2014

18.6K
Author Spotlight: A Computational Pipeline for Analyzing Chimeric Noncoding RNA-Target RNA Interactions in High-Throughput Sequencing Data
07:35

Author Spotlight: A Computational Pipeline for Analyzing Chimeric Noncoding RNA-Target RNA Interactions in High-Throughput Sequencing Data

Published on: December 1, 2023

1.2K

Main Results:

  • Demonstrated wide-scale involvement of miRNAs and lncRNAs in disease.
  • Highlighted specific examples across three major disease types.
  • Identified noncoding RNAs as critical players in pathophysiology.

Conclusions:

  • Noncoding RNAs are fundamentally involved in the development of major human diseases.
  • Understanding these roles opens avenues for novel therapeutic strategies.
  • Further research into noncoding RNAs promises significant clinical advancements.