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[Tooth and its supporting tissues regeneration using functional tooth modules].

W D Tian1

  • 1Department of Oral and Maxillofacial Surgery, West China Hospital of Stomatology, Sichuan University & State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & National Engineering Laboratory for Oral Regenerative Medicine, Chengdu 610041, China.

Zhonghua Kou Qiang Yi Xue Za Zhi = Zhonghua Kouqiang Yixue Zazhi = Chinese Journal of Stomatology
|July 6, 2018
PubMed
Summary
This summary is machine-generated.

Generating functional tissue modules using stem cells is key for tissue regeneration. This study explores strategies for creating functional tooth modules, aiming to advance tooth regeneration and clinical applications.

Keywords:
Functional tissue moduleStem cellsTissue engineering

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Area of Science:

  • Regenerative Medicine
  • Biomaterials Science
  • Dental Research

Background:

  • Stem cell-based functional tissue modules are emerging as a significant area in tissue regeneration.
  • These modules, formed via self-organization, cell sheets, electrospinning, or bioprinting, can be assembled into larger tissues and organs.
  • This technology offers a potential breakthrough for addressing limitations in current tissue regeneration and promoting clinical translation.

Purpose of the Study:

  • To review and discuss current strategies for constructing functional tooth modules.
  • To explore potential clinical applications of these modules, including dental pulp, periodontal tissue, and tooth root regeneration.
  • To highlight the need for further research in stem cell sources, preparation methods, and translational strategies for tooth regeneration.

Main Methods:

  • Review of existing literature and current understanding of stem cell-based tissue engineering.
  • Analysis of various methods for functional tissue module fabrication (self-organization, cell sheets, electrospinning, bioprinting).
  • Discussion of strategies for assembling modules for dental applications.

Main Results:

  • Functional tissue module construction is a rapidly developing field with broad applications in regenerative medicine.
  • The construction of functional tooth modules is still in its nascent stages, requiring further definition of stem cell sources and fabrication techniques.
  • Existing technologies need further investigation for their application in creating functional tooth modules.

Conclusions:

  • Functional tissue modules represent a promising approach for tissue and organ regeneration.
  • Significant research is still required to establish clear protocols for the construction and clinical application of functional tooth modules, particularly for dental regeneration.
  • This work provides insights into constructing strategies and potential clinical applications for functional tooth modules, aiming to advance tooth regeneration.