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[Early cellular immune exhaustion in patients with Epstein-Barr virus activation following haploidentical hematopoietic stem cell transplantation].

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Related Experiment Video

Updated: Feb 8, 2026

Author Spotlight: Optimizing Hairy Root-Based Transformation Protocols for Enhanced Efficiency in Brassicaceae
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[The key factors which affect the bio-root regeneration].

Z P Fan1

  • 1Beijing Key Laboratory of Tooth Regeneration and Function Reconstruction of Oral, Capital Medical University School of Stomatology, Beijing 100050, China.

Zhonghua Kou Qiang Yi Xue Za Zhi = Zhonghua Kouqiang Yixue Zazhi = Chinese Journal of Stomatology
|July 6, 2018
PubMed
Summary

Tooth regeneration using mesenchymal stem cells (MSC) shows promise for restoring lost teeth. Improving MSC dentinogenic differentiation within the jaw microenvironment is crucial for enhancing bio-root regeneration success.

Keywords:
Bio-rootCell differentiationMicroenvironmental nicheRegenerationStem cells

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Area of Science:

  • Biomaterials Science
  • Regenerative Medicine
  • Dental Research

Background:

  • Tooth loss is a significant health issue with current restorations having limitations.
  • Tooth regeneration using tissue engineering offers a potential alternative to conventional treatments.
  • The dental root is critical for tooth function, and its regeneration is a key focus.

Purpose of the Study:

  • To explore the potential of bio-root regeneration using mesenchymal stem cells (MSC).
  • To investigate factors influencing MSC-mediated bio-root regeneration.
  • To address the challenge of improving dentinogenic differentiation of MSC in the jaw microenvironment.

Main Methods:

  • Generation of bio-roots using MSC in a miniature pig model.
  • Analysis of factors affecting MSC differentiation, including the microenvironmental niche.
  • Focus on modulating the jaw microenvironment to promote dentinogenic differentiation.

Main Results:

  • Successful generation of bio-roots using MSC in miniature pigs was demonstrated.
  • The success rate of bio-root regeneration requires improvement for clinical application.
  • The jaw microenvironment typically favors osteogenic over dentinogenic differentiation of MSC.

Conclusions:

  • MSC-mediated bio-root regeneration is a promising approach for tooth restoration.
  • Optimizing the microenvironmental niche is essential for enhancing dentinogenic differentiation and bio-root regeneration success.
  • Further research is needed to overcome the challenges of directing MSC differentiation in the jaw for clinical translation.