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Related Experiment Video

Updated: Feb 8, 2026

Modeling Mitochondrial Disease Using Brain Organoids: A Focus on Mitochondrial Encephalomyopathy, Lactic Acidosis, and Stroke-like Episodes
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Persistent Lactic Acidosis: Thinking Outside the Box.

Hamza Arif1, Sohaib Zahid1, Amit Kaura2

  • 1Internal Medicine, Allegheny Health Network, Pittsburgh, USA.

Cureus
|July 6, 2018
PubMed
Summary

A patient with possible sepsis had persistently high lactic acid (LA) levels. This case highlights type B lactic acidosis caused by diffuse large B cell lymphoma, not sepsis.

Keywords:
diffuse large b-cell lymphoma (dlbcl)lactic acidosistype b lactic acidosis

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Area of Science:

  • Oncology
  • Internal Medicine
  • Critical Care Medicine

Background:

  • Sepsis is a common cause of elevated serum lactic acid (LA), often classified as type A lactic acidosis.
  • Persistent hyperlactatemia necessitates exploring differential diagnoses beyond sepsis, including type B lactic acidosis.

Observation:

  • A 54-year-old male presented with symptoms suggestive of sepsis and a significantly elevated serum LA of 18.7 mmol/L.
  • Standard sepsis treatment protocols and management of other type A lactic acidosis causes failed to resolve the patient's hyperlactatemia.

Findings:

  • The persistent elevation in LA was attributed to type B lactic acidosis.
  • The underlying cause identified was diffuse large B cell lymphoma.

Implications:

  • This case underscores the importance of considering malignancy-associated type B lactic acidosis in patients with unexplained persistent hyperlactatemia.
  • Understanding the mechanisms of lactic acidosis in lymphoma is crucial for effective patient management and treatment strategies.