Related Experiment Video
Updated: Feb 8, 2026
08:50
Assessment of Vascular Function in Patients With Chronic Kidney Disease
Published on: June 16, 2014
16.8K
Malnutrition in Chronic Kidney Disease
1Division of Nephrology, Phoenix Children's Hospital, Phoenix, AZ, United States.
Frontiers in Pediatrics
|July 6, 2018
Summary
Malnutrition, marked by protein energy wasting and micronutrient deficiency, is common in chronic kidney disease (CKD). Understanding its complex causes is key to effective treatment and better patient outcomes.
Area of Science:
- Nephrology
- Clinical Nutrition
- Pathophysiology
Background:
- Patients with chronic kidney disease (CKD) face a high risk of malnutrition, including protein energy wasting and micronutrient deficiencies.
- Malnutrition is prevalent in both pediatric and adult populations with CKD and contributes to stunted growth in children.
Purpose of the Study:
- To review the complex pathophysiologic mechanisms underlying malnutrition in patients with CKD.
- To highlight the necessity of understanding these mechanisms for developing effective interventions.
Main Methods:
- This article presents a review of existing literature on the pathophysiologic mechanisms of malnutrition in CKD.
- The review synthesizes information on hormonal, metabolic, inflammatory, and catabolic alterations.
Main Results:
- Malnutrition in CKD arises from a complex interplay of factors including decreased appetite, hormonal derangements, metabolic imbalances, inflammation, increased catabolism, and dialysis-related issues.
- Simple nutritional support (calories, protein) is often insufficient due to these multifaceted derangements.
Conclusions:
- Effective treatment of malnutrition in CKD requires a comprehensive understanding of its intricate pathophysiologic basis.
- Targeted strategies are needed to restore normal development and mitigate adverse clinical outcomes in CKD patients with malnutrition.
Keywords:
chronic kidney diseasedialysismalnutritionnutrient deficiencyprotein energy wastingundernutritionMore Related Videos
08:505/6th Nephrectomy in Combination with High Salt Diet and Nitric Oxide Synthase Inhibition to Induce Chronic Kidney Disease in the Lewis Rat
Published on: July 3, 2013
24.4K
10:51A Possible Zebrafish Model of Polycystic Kidney Disease: Knockdown of wnt5a Causes Cysts in Zebrafish Kidneys
Published on: December 2, 2014
11.5K
Related Concept Videos
01:25Chronic Kidney Disease I: Introduction
742
Chronic Kidney Disease (CKD) arises when the kidneys progressively lose their ability to function, ultimately leading to end-stage renal disease. At this advanced stage, the kidneys can no longer filter waste or maintain essential body functions, requiring renal replacement therapy (RRT) through dialysis or a kidney transplant for survival.Early-stage chronic kidney disease and detection challengesIn CKD's early stages, symptoms often remain absent because healthy nephrons compensate for...
742
01:24Chronic Kidney Disease II: Clinical Manifestations
673
Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
673
01:28Chronic Kidney Disease III: Interprofessional Care
481
Chronic kidney disease (CKD) requires collaborative and comprehensive management. CKD progresses through stages and can lead to end-stage kidney disease (ESKD) if untreated. Interprofessional collaboration and patient education are crucial, enabling patients to manage their health and improve their quality of life.Diagnostic approach for chronic kidney diseaseThe diagnosis of CKD primarily focuses on the glomerular filtration rate (GFR), which assesses kidney function by measuring how well...
481
01:18Chronic Kidney Disease IV: Nursing Management
401
Nursing management is essential for preventing complications, maintaining stability, and improving patients' quality of life in chronic kidney disease (CKD). By using a structured approach, nurses help slow CKD progression and support effective patient care.1. Comprehensive patient assessmentEffective management begins with nurses reviewing the patient’s medical history, and identifying key risk factors like diabetes, hypertension, and nephrotoxic drug use. Nurses assess signs of...
401
01:24Chronic Obstructive Pulmonary Disease
2.6K
COPD is defined as a heterogeneous lung condition marked by persistent respiratory symptoms such as dyspnea, cough, and sputum production, caused by abnormalities in the airways that cause airflow obstruction.
Smoking is a primary risk factor for COPD, with over 80% of patients having a history of it. Patients typically experience progressive dyspnea or labored breathing, frequent coughing, and recurrent pulmonary infections. Many eventually succumb to respiratory failure, characterized by...
Smoking is a primary risk factor for COPD, with over 80% of patients having a history of it. Patients typically experience progressive dyspnea or labored breathing, frequent coughing, and recurrent pulmonary infections. Many eventually succumb to respiratory failure, characterized by...
2.6K
01:20Chronic Obstructive Pulmonary Disease-II: Pathophysiology
4.6K
Chronic Obstructive Pulmonary Disease (COPD) pathophysiology is intricate and multifaceted, involving a complex interplay of physiological processes. Understanding these mechanisms is crucial for effectively managing and treating COPD. Here is an in-depth look at the critical elements in the pathophysiology of COPD:
Chronic Inflammation
Chronic Inflammation
4.6K