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Updated: Feb 8, 2026

Comprehensive Echocardiographic Assessment of Right Ventricle Function in a Rat Model of Pulmonary Arterial Hypertension
Published on: January 20, 2023
Arterial Stiffness in Hypertension: an Update.
Korshie Dumor1, Michael Shoemaker-Moyle2, Ravi Nistala2,3
1Division of Nephrology and Hypertension, Department of Medicine, University of Missouri School of Medicine, Columbia, MO, USA. Dumork@health.missouri.edu.
Novel insights into arterial stiffness mechanisms, measurements, and therapies are emerging. New techniques and treatments targeting factors like mineralocorticoid receptors may improve outcomes for hypertension complications.
Area of Science:
- Cardiovascular Medicine
- Nephrology
- Pharmacology
Background:
- Arterial stiffness is a predictor of cardiovascular and kidney disease.
- Aging is a known driver of arterial stiffness, but other mechanisms are under investigation.
- Accurate measurement of arterial stiffness is crucial for risk assessment.
Purpose of the Study:
- To review current understanding of arterial stiffness mechanisms.
- To explore advancements in measuring arterial stiffness.
- To discuss novel therapeutic strategies for managing arterial stiffness.
Main Methods:
- Review of recent scientific literature on arterial stiffness.
- Analysis of emerging technologies for pulse wave velocity (PWV) measurement.
- Evaluation of novel pharmacological targets and treatments.
Main Results:
- Increased interest in mechanisms beyond aging, including mineralocorticoid receptor, endothelial sodium channel (EnNaC), and uric acid.
- Development of improved PWV measurement techniques, such as single-point PWV.
- Exploration of anti-hypertensive and oral hypoglycemic agents as therapeutic approaches.
- Emerging data suggests potential for new therapies targeting specific pathways.
Conclusions:
- Newer techniques for measuring arterial stiffness (PWV) are being developed.
- Emerging data on mineralocorticoid receptor, EnNaC, and uric acid pathways offer potential therapeutic targets.
- Novel therapies and improved measurements may lead to better management of hypertension complications.
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Hypertension I: Introduction

