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Related Concept Videos

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The lungs are a pair of vital organs connected to the trachea via the left and right bronchi. The base of these organs meets the dome-shaped muscle known as the diaphragm. Encased by the pleurae, the lungs contact the mediastinum. The right lung is shorter yet wider, and has a larger volume than the left lung. The left lung has an indentation known as the cardiac notch. The superior region of the lungs is referred to as the apex, whereas the base is the lower region near the diaphragm. The...
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Related Experiment Video

Updated: Feb 8, 2026

Personalized Peptide Arrays for Detection of HLA Alloantibodies in Organ Transplantation
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Personalized Peptide Arrays for Detection of HLA Alloantibodies in Organ Transplantation

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HLA and lung transplantation.

Liya Ju1, Caroline Suberbielle2, Xiaofan Li3

  • 1HLA et Medecine, "Jean Dausset" Laboratory Network, Hôpital Saint-Louis, Paris, France. liya.ju@aphp.fr.

Frontiers of Medicine
|July 6, 2018
PubMed
Summary

HLA matching is crucial for lung transplant success, as antibodies against donor HLA antigens can cause rejection. This review examines HLA matching, antibody responses, and damage mechanisms in lung transplantation.

Keywords:
alloantibodyantibody mediated rejectionhuman leukocyte antigen class I and IIlung transplantationmismatchobliterans bronchiolitis

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Area of Science:

  • Immunology
  • Transplantation Science
  • Genetics

Background:

  • Lung transplantation is a growing treatment for end-stage lung disease.
  • Alloantibody production against donor Human Leukocyte Antigen (HLA) complexes hinders solid organ transplant success.
  • Antibody-mediated rejection (AMR) is well-defined in kidney and heart transplants but less characterized in lung transplants.

Purpose of the Study:

  • To review the significance of HLA matching in lung transplantation.
  • To summarize current knowledge on the allogenicity of HLA class I and II antigens.
  • To discuss the role of antibody-mediated immune responses and HLA antibodies in lung allograft outcomes.

Main Methods:

  • Literature review of studies on HLA matching in lung transplantation.
  • Analysis of data on HLA antigen allogenicity and antibody prevalence.
  • Discussion of immune response mechanisms and antibody-mediated damage in lung allografts.

Main Results:

  • The impact of HLA matching on lung transplant outcomes requires further characterization.
  • Understanding HLA antigen immunogenicity is key to managing AMR.
  • Pre- and post-transplant HLA antibodies are significant factors in lung allograft damage.

Conclusions:

  • HLA matching plays a critical role in mitigating antibody-mediated rejection after lung transplantation.
  • Further research is needed to fully elucidate the mechanisms of AMR in lung allografts.
  • Strategies targeting HLA antibodies may improve long-term lung transplant survival.