Skin flap squamous cell carcinoma developed after urethroplasty

To describe our experience in diagnosis and treatment of urethral carcinoma following urethroplasty with a Orandi penile skin flap.

Our patient underwent to Orandi penile skin flap urethroplasty then developed a urethral epidermoid carcinoma on the flap approximately 15 years later. We treated this case with a partial penectomy surgery and perineostomy. Surgery was followed by chemotherapy with cisplatin and 5-fluorouracil. The progression of the disease led to a salvage surgery of total penectomy and asportation of testicles and scrotum.

Despite the success of the surgery, the disease progressed and three months after the last surgical operation the patient died.

Urethral carcinoma on skin flap is a rare complication of the urethroplasty surgery but with severe consequences, so we recommend to undertake a long-term urological follow up in patients undergone such kind of surgery.