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[Obesity treatment with liraglutide in a patient with Prader-Willi syndrome: a case report]

Diego Andrés Cadena-Obando1, Mario Antonio Molina-Ayala, Aldo Ferreira-Hermosillo

  • 1Servicio de Endocrinología. Hospital de Especialidades. Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social. dacocadena@gmail.com.

Nutricion Hospitalaria
|July 6, 2018
PubMed

Insights

Prader-Willi syndrome (PWS) management is challenging. Liraglutide, diet, and exercise helped a patient achieve weight loss and control, offering a potential treatment pathway.

Area of Science:

  • Genetics and Endocrinology
  • Metabolic Disorders

Background:

  • Prader-Willi syndrome (PWS) is a genetic disorder causing syndromic obesity due to chromosome 15q11-q13 deletions.
  • Key PWS features include neonatal hypotonia, feeding difficulties, hyperphagia, behavioral issues, and obesity.
  • Limited and controversial weight management options exist for PWS patients, including surgical approaches.

Purpose of the Study:

  • To report a case of successful weight management in a patient with Prader-Willi syndrome.
  • To highlight the potential role of liraglutide in conjunction with lifestyle interventions for PWS obesity.

Main Methods:

  • A case report detailing the treatment of a patient diagnosed with Prader-Willi syndrome.
  • The intervention involved liraglutide, a structured nutritional therapy plan, and a consistent physical activity regimen.

Main Results:

  • The patient achieved significant weight loss.
  • Effective control over appetite and weight was maintained through the combined treatment approach.

Conclusions:

  • Obesity treatment in PWS is complex, necessitating integrated nutritional and psychological support.
  • Medications like metformin or GLP-1 receptor agonists (e.g., liraglutide) are viable options for patients with persistent hyperphagia.
Abstract

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