Related Experiment Video
Updated: Feb 8, 2026
08:00
Derivation of Cardiac Progenitor Cells from Embryonic Stem Cells
Published on: January 12, 2015
8.6K
Influence of injectable microparticle size on cardiac progenitor cell response
Elisabetta Rosellini1, Niccoletta Barbani1, Caterina Frati2
11 Department of Civil and Industrial Engineering, University of Pisa, Pisa, Italy.
Summary
Novel gelatin/gellan microparticles show potential as injectable scaffolds for myocardial repair. Smaller particle sizes enhanced cardiac progenitor cell adhesion, suggesting a promising strategy for tissue engineering.
Area of Science:
- Biomaterials Science
- Regenerative Medicine
- Cardiovascular Engineering
Background:
- Injectable scaffolds are crucial for myocardial tissue engineering.
- Microparticle-based scaffolds remain underexplored.
- This study focuses on developing gelatin/gellan microparticles for infarcted myocardium repair.
Purpose of the Study:
- To develop novel gelatin/gellan microparticles as injectable scaffolds.
- To investigate the impact of microparticle size on cardiac progenitor cell response.
- To assess the potential for myocardial regeneration applications.
Main Methods:
- Fabrication of microparticles using a water-in-oil emulsion method with phosphatidylcholine.
- Production of particles in two distinct size ranges (125-300 µm and 350-450 µm).
- Comprehensive characterization including morphology, physicochemical properties, degradation, injectability, and in vitro cell culture.
Main Results:
- Spherical, porous microparticles with hydrophilic properties and intermolecular interactions were produced.
- Particles exhibited significant hydrolytic degradation (75% over 90 days) and were injectable through a 26 G needle.
- In vitro studies demonstrated preserved cardiac progenitor cell viability and preferential adhesion to smaller microparticles.
Conclusions:
- Gelatin/gellan microparticles show promise as injectable scaffolds for myocardial regeneration.
- Particle size is a critical factor influencing cardiac progenitor cell interaction.
- Further development could lead to effective treatments for infarcted myocardium.
More Related Videos
Related Concept Videos
01:22Cell Size
129.2K
Cell sizes vary widely among and within organisms. Bacterial cells range between 1-10 micrometers (μm)and are considerably smaller than most eukaryotic cells. The smallest bacteria are 0.1 μm in diameter—about a thousand times smaller than eukaryotic cells, which typically range from 10-100 μm.
Surface Area
Cells can take in nutrients and water via diffusion through the plasma membrane itself or through specific channels in the membrane. The area of the membrane surrounding...
Surface Area
Cells can take in nutrients and water via diffusion through the plasma membrane itself or through specific channels in the membrane. The area of the membrane surrounding...
129.2K
01:15Chronopharmacokinetics: Circadian Rhythms and Influence on Drug Response
371
Circadian rhythms are cyclic changes that are crucial in plasma drug concentrations. Various standard circadian parameters, including core body temperature, heart rate, and other cardiovascular factors, directly impact disease states and the therapeutic response to drug therapy.
The time of drug administration is an important factor to consider, as it can influence the toxic dose of a drug. For example, a study conducted by Prins et al. in 1997 examined the effects of the timing of...
The time of drug administration is an important factor to consider, as it can influence the toxic dose of a drug. For example, a study conducted by Prins et al. in 1997 examined the effects of the timing of...
371
01:15Differentiation of Common Myeloid Progenitor Cells
4.0K
Common myeloid progenitors (CMPs) are oligopotent cells that can differentiate into granulocytes and macrophages. Granulocytes and macrophages are essential for protecting the body against bacterial, viral, or fungal infections. They migrate from the bone marrow into the circulating blood to reach specific tissue sites where they differentiate and help in immune surveillance. However, they survive only for a few days and must be continuously made available to the organism to maintain a robust...
4.0K
02:45Responses to Heat and Cold Stress
14.9K
Every organism has an optimum temperature range within which healthy growth and physiological functioning can occur. At the ends of this range, there will be a minimum and maximum temperature that interrupt biological processes.
14.9K
03:21Genome Size and the Evolution of New Genes
9.2K
While every living organism has a genome of some kind (be it RNA, or DNA), there is considerable variation in the sizes of these blueprints. One major factor that impacts genome size is whether the organism is prokaryotic or eukaryotic. In prokaryotes, the genome contains little to no non-coding sequence, such that genes are tightly clustered in groups or operons sequentially along the chromosome. Conversely, the genes in eukaryotes are punctuated by long stretches of non-coding sequence.
9.2K
01:22Diversity in Cell Signaling Responses
8.0K
The physiological function of a cell and cellular communication are outcomes of a range of extrinsic signals, intracellular signaling pathways, and cellular responses. No two cell types express the same repertoire of signaling components. Receptors are highly selective for their cognate ligands, but once activated, they can alter multiple cellular processes such as DNA transcription, protein synthesis, and metabolic activity.
Graded and Abrupt Responses
Some signaling systems generate...
Graded and Abrupt Responses
Some signaling systems generate...
8.0K