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Updated: Feb 8, 2026

Establishing a Mouse Model of a Pure Small Fiber Neuropathy with the Ultrapotent Agonist of Transient Receptor Potential Vanilloid Type 1
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Establishing a Mouse Model of a Pure Small Fiber Neuropathy with the Ultrapotent Agonist of Transient Receptor Potential Vanilloid Type 1

Published on: February 13, 2018

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Sustenance of endothelial cell stability in septic mice through appropriate activation of transient receptor

Yi-Hua Zhu1, Zhen-Ming Pei1

  • 1College of Life Sciences, Zhejiang University, Hangzhou, China.

Cellular and Molecular Biology (Noisy-Le-Grand, France)
|July 6, 2018
PubMed

Insights

Transient Receptor Potential Vanilloid-4 (TRPV-4) activation, not inhibition, is crucial in sepsis. Proper TRPV-4 activation levels are vital for maintaining normal physiological function during sepsis.

Area of Science:

  • Physiology
  • Pharmacology
  • Immunology

Background:

  • Transient Receptor Potential Vanilloid-4 (TRPV-4) is a therapeutic target in endotoxemia research.
  • Previous studies reported HC067047, a TRPV-4 inhibitor, mitigated LPS-induced injury.
  • Conflicting results exist regarding TRPV-4 inhibition's effect on LPS-induced symptoms and pathology.

Purpose of the Study:

  • To investigate the conflicting results regarding TRPV-4 inhibition in LPS-induced sepsis.
  • To determine the effects of different doses of TRPV-4 inhibitor on sepsis-related physiological indicators.
  • To elucidate the role of TRPV-4 activation in sepsis.

Main Methods:

  • Administered varying doses of a TRPV-4 inhibitor in a sepsis model.
  • Assessed sepsis-related physiological indicators, including endothelial injury markers, coagulation index, organ damage, inflammatory factors, and cell apoptosis.
  • Compared outcomes between different inhibitor concentrations and sepsis severity.

Main Results:

  • Neither high nor low levels of the TRPV-4 inhibitor significantly affected sepsis-related physiological indicators.
  • TRPV-4 inhibition did not attenuate LPS-induced symptoms or improve pathology.
  • Exaggerated pathology was observed with TRPV-4 inhibition.

Conclusions:

  • Proper activation of TRPV-4 is important for maintaining normal physiological function during sepsis.
  • The degree of TRPV-4 activation should be matched to the severity of sepsis.
  • TRPV-4 inhibition may not be a suitable therapeutic strategy for LPS-induced sepsis.
Keywords:
Endothelial injury.HC06047LipopolysaccharideSepsisTransient receptor potential vanilloid 4

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