Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Recent advances in Barrett's esophagus.

John Inadomi1, Hani Alastal2,3, Luigi Bonavina4,5

  • 1Division of Gastroenterology, University of Washington School of Medicine, Seattle, Washington.

Annals of the New York Academy of Sciences
|July 6, 2018
PubMed
Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Advancing fair and explainable machine learning for neuroimaging dementia pattern classification in multi-racial and multi-ethnic populations.

Nature communications·2026
Same author

Can artificial intelligence fulfill its potential to improve health and reduce costs?

Endoscopy·2026
Same author

If You Want to Go Far, Go Together: Lessons Learned from Quality Improvement Collaboratives in Palliative Care.

Journal of palliative medicine·2026
Same author

Translational Modeling of Gut Microbiome-Mediated Drug Metabolism: A Case Example of Sulfasalazine.

CPT: pharmacometrics & systems pharmacology·2026
Same author

Impact of missing patient report outcomes in clinical trials for ulcerative colitis: Should we always assume treatment failure?

Crohn's & colitis 360·2026
Same author

ISGylation of γH2AX retains MDC1 and facilitates homologous recombination repair causing radioresistance in esophageal adenocarcinoma.

The Journal of biological chemistry·2026

Barrett's esophagus (BE) is a precursor to esophageal adenocarcinoma. Further research is needed to understand BE development, identify high-risk individuals, and optimize treatment for this condition.

Area of Science:

  • Gastroenterology and Oncology
  • Esophageal Disease Research

Background:

  • Barrett's esophagus (BE) is the primary precursor to esophageal adenocarcinoma, a cancer with rising incidence.
  • The cellular origin and malignant transformation pathways of BE remain incompletely understood.
  • Current risk stratification tools are insufficient to guide intervention for individuals with BE.

Purpose of the Study:

  • To explore the pathogenesis of Barrett's esophagus, including cellular origins and malignant transformation.
  • To identify improved methods for risk stratification in BE patients.
  • To optimize endoscopic eradication therapy and surveillance strategies for BE.

Main Methods:

  • Review of current research on BE pathogenesis.
  • Analysis of data regarding stem cell origins in BE.
Keywords:
Barrett's esophagusendoscopyesophageal adenocarcinomaimagingscreeningsurveillance

Related Experiment Videos

  • Evaluation of endoscopic eradication therapy and medical/nonmedical interventions for reflux reduction.

    • Main Results:

    • Recent data suggest a possible junctional origin of stem cells for BE.
    • Effective BE remission requires reduction of gastroesophageal reflux.
    • Lack of discriminatory tools for identifying high-risk BE patients necessitates further research.

    Conclusions:

    • Understanding BE pathogenesis is crucial for cancer prevention.
    • Development of better risk stratification tools is essential for targeted BE treatment.
    • Optimizing eradication therapy and surveillance is key to maintaining BE remission and preventing cancer.