Multiple Multicomponent Reactions: Unexplored Substrates, Selective Processes, and Versatile Chemotypes in...

Area of Science:

• Organic Chemistry
• Medicinal Chemistry
• Synthetic Chemistry

Background:

• Multicomponent reactions (MCRs) are efficient for synthesizing complex molecules.
• However, limited selectivity and transformations hinder their widespread synthetic application.

Purpose of the Study:

• To develop a selective approach for MCRs.
• To enable the synthesis of novel heterocyclic scaffolds with biological relevance.

Main Methods:

• A novel strategy based on preferential generation of less reactive intermediates was devised.
• The Groebke-Blackburn-Bienaymé reaction was applied to α-polyamino-polyazines.

Main Results:

• A family of compact heterocyclic scaffolds was synthesized.
• The method demonstrated general applicability, yielding complex molecular targets selectively and directly.
• The synthesized compounds show potential as live cell imaging probes, DNA quadruplex binders, and antiviral agents.

Conclusions:

• The developed strategy offers a selective and tunable approach to MCRs.
• This method provides direct access to complex heterocyclic scaffolds for diverse applications in chemistry and biology.