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Related Experiment Video

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Non-plasma Bonding of PDMS for Inexpensive Fabrication of Microfluidic Devices
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Fluoropolymer-Coated PDMS Microfluidic Devices for Application in Organic Synthesis.

Tianjin Yang1, Jaebum Choo2, Stavros Stavrakis1

  • 1Institute for Chemical and Bioengineering, Department of Chemistry and Applied Biosciences, ETH Zürich, Vladimir Prelog Weg 1, 8093, Zürich, Switzerland.

Chemistry (Weinheim an Der Bergstrasse, Germany)
|July 6, 2018
PubMed
Summary
This summary is machine-generated.

This study introduces a new method for creating robust microfluidic reactors for chemical synthesis. Coating polydimethylsiloxane (PDMS) with CYTOP polymer enhances its chemical resistance, enabling its use in demanding organic synthesis applications.

Keywords:
fluoropolymermicrofluidicsmicroreactororganic synthesis

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Area of Science:

  • Chemical Engineering
  • Materials Science
  • Organic Synthesis

Background:

  • Microfluidic reactors offer precise control for synthesizing small molecules and nanomaterials.
  • Traditional microfluidic devices made from rigid materials are complex and expensive to fabricate.
  • There is a need for solvent-resistant microfluidic devices manufacturable via soft-lithography.

Purpose of the Study:

  • To develop a simplified method for creating solvent-resistant microfluidic reactors.
  • To demonstrate the utility of CYTOP as a coating to enhance PDMS chemical inertness.
  • To validate the performance of CYTOP-coated PDMS in challenging organic synthesis reactions.

Main Methods:

  • Coating polydimethylsiloxane (PDMS) with CYTOP, a perfluorinated polymer.
  • Fabrication of microfluidic devices using soft-lithographic prototyping.
  • Testing the performance of the modified microfluidic devices in photooxidation reactions.
  • Evaluating device performance under extreme acidic and basic conditions.

Main Results:

  • CYTOP coating effectively transforms PDMS into a chemically inert material.
  • The modified PDMS microfluidic devices demonstrated successful performance in photooxidation reactions.
  • The devices maintained integrity and functionality under extremely acidic and basic conditions.
  • This method offers a cost-effective and simplified approach to producing robust microfluidic reactors.

Conclusions:

  • Coating PDMS with CYTOP is a viable strategy for creating solvent-resistant microfluidic reactors.
  • This approach expands the applicability of PDMS-based microfluidics in organic synthesis.
  • The developed method provides a practical solution for fabricating durable and versatile microfluidic devices for chemical synthesis.