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Updated: Feb 8, 2026

Efficient and Cost Effective Electroporation Method to Study Primary Cilium-Dependent Signaling Pathways in the Granule Cell Precursor
Published on: November 30, 2021
PASI: A novel pathway method to identify delicate group effects
Maria K Jaakkola1,2, Aidan J McGlinchey1, Riku Klén1
1Turku Centre for Biotechnology, University of Turku and Åbo Akademi University, Turku, Finland.
Abstract:
Pathway analysis is a common approach in diverse biomedical studies, yet the currently-available pathway tools do not typically support the increasingly popular personalized analyses. Another weakness of the currently-available pathway methods is their inability to handle challenging data with only modest group-based effects compared to natural individual variation. In an effort to address these issues, this study presents a novel pathway method PASI (Pathway Analysis for Sample-level Information) and demonstrates its performance on complex diseases with different levels of group-based differences in gene expression. PASI is freely available as an R package.
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