Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Load-frequency control01:28

Load-frequency control

675
Load-frequency control (LFC) is vital for maintaining power system stability, ensuring that frequency and power flows remain within acceptable limits during load changes. Turbine-governor control eliminates rotor accelerations and decelerations following load changes. However, a steady-state frequency error persists when the change in the turbine-governor reference setting is zero. In an interconnected power system, each area agrees to export or import a scheduled amount of power through...
675
Impact Loading01:19

Impact Loading

708
Impact loading occurs when a moving object collides with a stationary structure, such as a rod with a uniform cross-sectional area fixed at one end. Under these conditions, the rod absorbs the kinetic energy from the striking object, leading to deformation and subsequent stress development. As the rod returns to its original position and reaches maximum stress, the absorbed energy, initially manifested as kinetic energy, transforms entirely into strain energy.
In cases of elastic deformation,...
708
Distributed Loads01:19

Distributed Loads

978
Distributed loads are a common type of load that engineers and scientists encounter in various practical situations. Distributed loads often refer to a type of load spread over a surface or a structure and can be modeled as continuous force per unit area.
For example, consider a bookshelf filled with books stacked vertically adjacent to each other. The weight of the books is evenly distributed over the length of the shelf. As a result, the pressure at different locations on the surface of the...
978
Eccentric Loading01:16

Eccentric Loading

1.0K
Eccentric loading is a crucial concept in the study of structural engineering and mechanics, particularly when analyzing the stability and stress distribution in columns. Unlike centric loading, where the force is applied along the centroidal axis, causing uniform compression, eccentric loading occurs when a force is applied off-center. This off-center application introduces not only direct compressive stress but also bending stress, significantly influencing the column's behavior under...
1.0K
Combinatorial Gene Control02:33

Combinatorial Gene Control

9.7K
Combinatorial gene control is the synergistic action of several transcriptional factors to regulate the expression of a single gene. The absence of one or more of these factors may lead to a significant difference in the level of gene expression or repression.
The expression of more than 30,000 genes is controlled by approximately 2000-3000 transcription factors. This is possible because a single transcription factor can recognize more than one regulatory sequence. The specificity in gene...
9.7K
Load along a Single Axis01:29

Load along a Single Axis

647
In structural engineering, the analysis of beams subjected to varying loads is a critical aspect of understanding the behavior and performance of these structural elements. A common scenario involves a beam subjected to a combination of different load distributions.
Consider a beam of length L subjected to a varying load, which is a combination of parabolic and trapezoidal load distribution along the x-axis. In this case, it is essential to determine the resultant loads, their locations, and...
647

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

High-resolution structure of monomorphic Aβ<sub>1-40</sub> fibrils.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same author

Effects of solution conditions on the self-assembly of the chaperone protein DNAJB6b.

Communications chemistry·2025
Same author

Improved prediction of site-rates from structure with averaging across homologs.

Protein science : a publication of the Protein Society·2024
Same author

Accurate prediction of protein assembly structure by combining AlphaFold and symmetrical docking.

Nature communications·2023
Same author

Atomistic simulation of protein evolution reveals sequence covariation and time-dependent fluctuations of site-specific substitution rates.

PLoS computational biology·2023
Same author

DnaK response to expression of protein mutants is dependent on translation rate and stability.

Communications biology·2022

Related Experiment Video

Updated: Feb 8, 2026

Directed Assembly of Elastin-like Proteins into defined Supramolecular Structures and Cargo Encapsulation In Vitro
10:01

Directed Assembly of Elastin-like Proteins into defined Supramolecular Structures and Cargo Encapsulation In Vitro

Published on: April 8, 2020

6.4K

A Protein-Based Encapsulation System with Calcium-Controlled Cargo Loading and Detachment.

Robert Lizatović1, Marvin Assent1, Arjan Barendregt2

  • 1Biochemistry and Structural Biology, Lund University, PO BOX 124, Lund, Sweden.

Angewandte Chemie (International Ed. in English)
|July 6, 2018
PubMed
Summary

Researchers developed a novel protein encapsulation system using hepatitis B virus capsids. This system allows controlled release of cargo molecules within the capsid, enabling targeted delivery and catalysis applications.

Keywords:
fluorescence correlation spectroscopyhepatitis Bprotein designself-assemblyvirus-like particles

More Related Videos

Cargo Loading onto Kinesin Powered Molecular Shuttles
09:00

Cargo Loading onto Kinesin Powered Molecular Shuttles

Published on: November 3, 2010

11.0K
Targeted Plasma Membrane Delivery of a Hydrophobic Cargo Encapsulated in a Liquid Crystal Nanoparticle Carrier
10:16

Targeted Plasma Membrane Delivery of a Hydrophobic Cargo Encapsulated in a Liquid Crystal Nanoparticle Carrier

Published on: February 8, 2017

8.0K

Related Experiment Videos

Last Updated: Feb 8, 2026

Directed Assembly of Elastin-like Proteins into defined Supramolecular Structures and Cargo Encapsulation In Vitro
10:01

Directed Assembly of Elastin-like Proteins into defined Supramolecular Structures and Cargo Encapsulation In Vitro

Published on: April 8, 2020

6.4K
Cargo Loading onto Kinesin Powered Molecular Shuttles
09:00

Cargo Loading onto Kinesin Powered Molecular Shuttles

Published on: November 3, 2010

11.0K
Targeted Plasma Membrane Delivery of a Hydrophobic Cargo Encapsulated in a Liquid Crystal Nanoparticle Carrier
10:16

Targeted Plasma Membrane Delivery of a Hydrophobic Cargo Encapsulated in a Liquid Crystal Nanoparticle Carrier

Published on: February 8, 2017

8.0K

Area of Science:

  • Biotechnology
  • Protein Engineering
  • Nanotechnology

Background:

  • Protein-based encapsulation systems are vital for targeted delivery and confined chemical reactions.
  • Current systems lack control over cargo release after encapsulation.
  • Releasing cargo is crucial for drug delivery and using capsids as catalytic nanoparticles.

Purpose of the Study:

  • To engineer a controllable protein encapsulation system using hepatitis B virus (HBV) capsids.
  • To enable tunable release of cargo molecules from within the capsid.
  • To demonstrate the utility of this system for catalysis.

Main Methods:

  • Engineered high-affinity interactions between cargo and HBV capsid proteins.
  • Utilized calcium ions (Ca2+) to modulate the cargo-capsid interaction.
  • Encapsulated cargo proteins and an enzyme with beta-glucosidase activity.

Main Results:

  • Developed a Ca2+-modulated system for efficient cargo loading and subsequent release.
  • Observed hindered rotation of encapsulated cargo due to confinement.
  • Demonstrated the catalytic application of the engineered HBV capsid system.

Conclusions:

  • The engineered HBV capsid system offers controllable cargo encapsulation and release.
  • This system has potential applications in drug delivery and nanoparticle catalysis.
  • Confinement within the capsid influences cargo dynamics.