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Epidemiology and Genetic Diversity of Rotavirus in Kunming, China, in 2015

Yongbo Kang1,2,3,4, Yue Cai2,4

  • 1School of Basic Medical Sciences, Shanxi Medical University, Taiyuan, China.

Intervirology
|July 6, 2018
PubMed

Insights

Group A rotavirus (RVA) is a significant cause of diarrhea in young children in China. This study identified common RVA strains, highlighting the need for vaccination to control RVA-related illness.

Area of Science:

  • Virology
  • Public Health
  • Epidemiology

Background:

  • Group A rotavirus (RVA) poses a significant public health challenge in China, particularly among children under five years of age.
  • Previous studies indicate a substantial prevalence of RVA in pediatric diarrhea cases.

Purpose of the Study:

  • To investigate the molecular epidemiology, genetic diversity, and prevalence of Group A rotavirus strains.
  • To characterize RVA strains circulating in children under five with acute gastroenteritis in Kunming, China.

Main Methods:

  • Collection and analysis of 1,224 fecal specimens from children under five with acute gastroenteritis in Kunming, China, during 2015.
  • Detection and molecular characterization of rotavirus strains, including G and P genotyping.

Main Results:

  • The overall prevalence of RVA was 28.5%, with the highest detection rate (52%) observed in children aged 7-12 months.
  • The most common RVA strains identified were G9P(8) (58.2%), G3P(8) (14.9%), and G1P(8) (6.9%).
  • Several uncommon and mixed RVA strains were also detected, indicating genetic diversity.

Conclusions:

  • The study provides crucial data on the molecular epidemiology and genetic diversity of RVA strains in Kunming, China.
  • Findings suggest the importance of RVA vaccination and evidence-based strategies for controlling RVA-related diarrhea in young children.

Keywords:
DiarrheaEpidemiologyG and P typesRotavirus

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