Related Experiment Video

Updated: Feb 8, 2026

Myocardial Infarction and Functional Outcome Assessment in Pigs
12:03

Myocardial Infarction and Functional Outcome Assessment in Pigs

Published on: April 25, 2014

28.7K

Effects of Short-term High Dose Atorvastatin on Left Ventricular Remodeling in Patients with First Time Attack of

Zhi-Jian Liu1, Gao-Pin Hu1, Mei-Ying Fei1

  • 1Department of Cardiology, the 210th Hospital of People's Liberation Army, Dalian, Liaoning 116021, China.

Chinese Medical Sciences Journal = Chung-Kuo I Hsueh K'O Hsueh Tsa Chih
|July 7, 2018
PubMed

Insights

Short-term high-dose atorvastatin therapy for acute anterior myocardial infarction (AAMI) reduced inflammatory markers like hs-CRP, ET-1, and MMP-9. However, this intensive treatment did not significantly improve left ventricular remodeling compared to standard dosing.

Area of Science:

  • Cardiology
  • Pharmacology
  • Biochemistry

Background:

  • Acute anterior myocardial infarction (AAMI) is a critical cardiovascular event.
  • Inflammatory markers and ventricular remodeling are key indicators of AAMI prognosis.
  • Atorvastatin is a widely used statin for cardiovascular disease management.

Purpose of the Study:

  • To evaluate the impact of short-term high-dose atorvastatin on inflammatory markers and left ventricular (LV) remodeling in AAMI patients.
  • To compare intensive treatment (40mg then 20mg) versus standard treatment (20mg) of atorvastatin.

Main Methods:

  • 103 AAMI patients undergoing percutaneous coronary intervention were randomized into intensive (IT) and standard (ST) atorvastatin groups.
  • Plasma levels of hs-CRP, MDA, ET-1, MMP-2, and MMP-9 were measured at baseline and follow-up points.
  • Echocardiography assessed LV remodeling (LVEDV, LVESV, LVEF) at baseline, 2 weeks, and 1 year.

Main Results:

  • The IT group showed significantly lower levels of hs-CRP, ET-1, MMP-9, and pro-BNP at 1 week post-AAMI compared to the ST group.
  • No significant differences were observed in the changes of LVEDV, LVESV, and LVEF at 1-year follow-up between the IT and ST groups.
  • Malondialdehyde (MDA) levels were also measured but not explicitly detailed in the provided results summary.

Conclusions:

  • Short-term high-dose atorvastatin therapy in AAMI patients leads to a reduction in specific inflammatory markers and endothelin-1.
  • The observed reduction in inflammatory markers with intensive atorvastatin treatment does not translate to improved left ventricular remodeling at one year.
  • Further research may be needed to elucidate the long-term clinical implications of these findings.

More Related Videos

Acute Myocardial Infarction in Rats07:45

Acute Myocardial Infarction in Rats

Published on: February 16, 2011

54.7K
Permanent Ligation of the Left Anterior Descending Coronary Artery in Mice: A Model of Post-myocardial Infarction Remodelling and Heart Failure09:37

Permanent Ligation of the Left Anterior Descending Coronary Artery in Mice: A Model of Post-myocardial Infarction Remodelling and Heart Failure

Published on: December 2, 2014

28.7K

Related Concept Videos

Drug Dosing: Geriatric Patients01:15

Drug Dosing: Geriatric Patients

Elderly individuals encompass a diverse population with varying degrees of age-related physiological changes. Defining the elderly presents challenges, as the geriatric population is often arbitrarily categorized as individuals older than 65. However, many individuals in this group lead active and healthy lives, with an increasing number surpassing 85 years and falling into the older elderly category. Physiological changes associated with aging impact performance capacity and homeostatic...
278
Drug Dosing: Obese Patients01:21

Drug Dosing: Obese Patients

In the United States, obesity is a prominent concern. It is linked to heightened mortality rates due to increased occurrences of conditions such as hypertension, atherosclerosis, coronary artery disease, and diabetes compared to nonobese individuals. A patient is classified as obese if their actual body weight surpasses the ideal or desirable body weight by 20%, based on Metropolitan Life Insurance Company data. Ideal body weights consider average weights and heights for males and females...
269
Insulin: Dosing Regimen and Adverse Effects01:16

Insulin: Dosing Regimen and Adverse Effects

Insulin-replacement therapy usually includes both long-acting insulin (basal) and short-acting insulin (to cater to postprandial needs). In a diverse group of type 1 diabetes patients, the average daily insulin dose is typically 0.5-0.7 units/kg body weight. However, obese patients and pubertal adolescents may need more due to insulin resistance.
The basal dose constitutes about 40%-50% of the total daily dose, with the rest as premeal insulin. The mealtime insulin dose should mirror...
806
Nucleosome Remodeling02:54

Nucleosome Remodeling

Nucleosomes are the basic units of chromatin compaction. Each nucleosome consists of the DNA bound tightly around a histone core, which makes the DNA inaccessible to DNA binding proteins such as DNA polymerase and RNA polymerase. Hence, the fundamental problem is to ensure access to DNA when appropriate, despite the compact and protective chromatin structure.
Nucleosome remodeling complex
Eukaryotic cells have specialized enzymes called ATP-dependent nucleosome remodeling enzymes. These enzymes...
11.2K
Acid Attack on Concrete01:21

Acid Attack on Concrete

When acids come into contact with concrete, they initiate a chemical reaction that dissolves the hydrated cement paste. This process leads to softening and structural weakening of the concrete. This issue is commonly observed in environments such as chimneys, sewers, and industrial settings. The severity of the damage increases as the pH of the water interacting with the concrete drops below 6.5. In particular, a pH under 4.5 can cause significant concrete damage.
The rate at which hydrogen...
770
Pharmacodynamics in Geriatric Patients: Effects of Age01:27

Pharmacodynamics in Geriatric Patients: Effects of Age

Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...
239