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Recent progress in natural dietary non-phenolic bioactives on cancers metastasis

Gow-Chin Yen1,2, Chiung-Man Tsai1,3, Chi-Cheng Lu4

  • 1Department of Food Science and Biotechnology, National Chung Hsing University, Taichung, Taiwan.

Journal of Food and Drug Analysis
|July 7, 2018
PubMed

Insights

Natural compounds, excluding phenolics, show promise in preventing cancer metastasis. This review details their anti-cancer effects and mechanisms, aiding in understanding dietary bioactive contributions to cancer prevention.

Area of Science:

  • Oncology
  • Nutraceuticals
  • Molecular Biology

Background:

  • Cancer metastasis is a primary cause of cancer-related mortality worldwide.
  • Nutraceutical supplementation is a sought-after non-chemical therapy for disease prevention.
  • Over 10,000 natural bioactives are known for potential health benefits, including anti-cancer effects.

Purpose of the Study:

  • To review recent studies on the in vitro and in vivo effects of non-phenolic natural bioactives on cancer invasion and metastasis.
  • To elucidate the molecular mechanisms underlying the anti-metastatic activities of these compounds.
  • To provide a comprehensive understanding of dietary bioactives' role in inhibiting cancer progression.

Main Methods:

  • Literature review of studies published in the last decade.
  • Focus on in vitro and in vivo research.
  • Analysis of molecular mechanisms of action for non-phenolic natural compounds.

Main Results:

  • Numerous non-phenolic natural dietary compounds exhibit anti-invasive and anti-metastatic properties against various cancers.
  • These compounds act through diverse molecular pathways to inhibit cancer cell invasion and metastasis.
  • The review consolidates evidence on the efficacy of these non-phenolic bioactives.

Conclusions:

  • Non-phenolic natural bioactives represent a significant area for cancer prevention and therapy.
  • Understanding their mechanisms complements existing knowledge on phenolic compounds.
  • This comprehensive review contributes to a clearer picture of dietary bioactives in combating cancer metastasis.
Keywords:
AngiogenesisInvasionMetastasisNatural dietary bioactives

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